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Tbio
FAF1
FAS-associated factor 1

Protein Summary
Description
Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396153
  • ENSP00000379457
  • ENSG00000185104

Symbol
  • UBXD12
  • UBXN3A
  • hFAF1
  • CGI-03
  • HFAF1s
  • UBXD12
  • UBXN3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
disease perturbation
0.9
interacting protein
0.9
transcription factor perturbation
0.88
biological process
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.78   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.78   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
2
1.1
98.1
balding measurement
1
1
1
90.9
sex hormone-binding globulin measurement
3
2
3
88.7
triglyceride measurement
2
2
2
82.9
testosterone measurement
1
1
1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
98.1
balding measurement
1
90.9
sex hormone-binding globulin measurement
3
88.7
triglyceride measurement
2
82.9
testosterone measurement
1
74.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fas associated factor 1
VGNC:6815
456846
Macaque
Fas associated factor 1
714405
Mouse
MGI:109419
14084
Rat
RGD:70987
140657
Dog
Fas associated factor 1
VGNC:40567
608231
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fas associated factor 1
Macaque
Fas associated factor 1
Mouse
Rat
Dog
Fas associated factor 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UNN5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (25)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (110)
1 – 10 of 110
BHLHA15
Tbio
Family: TF
Novelty: 0.02721846
p_int: 0.999944932
p_ni: 0.000055068
Data Source: BioPlex
TCEAL1
Tbio
Novelty: 0.02210924
p_int: 0.99954722
p_ni: 0.00045278
Score: 0.173
Data Source: BioPlex,STRINGDB
CHCHD10
Tbio
Novelty: 0.01659548
p_int: 0.997725669
p_ni: 0.002274331
Score: 0.16
Data Source: BioPlex,STRINGDB
CHCHD2
Tbio
Novelty: 0.01615338
p_int: 0.997292332
p_ni: 0.002707668
Data Source: BioPlex
MAGIX
Tdark
Novelty: 0.38577176
p_int: 0.995563383
p_ni: 0.004436617
Score: 0.264
Data Source: BioPlex,STRINGDB
CLEC3A
Tdark
Novelty: 0.21498836
p_int: 0.980696819
p_ni: 0.019303181
Score: 0.16
Data Source: BioPlex,STRINGDB
DDX54
Tbio
Family: Enzyme
Novelty: 0.12769464
p_int: 0.967147745
p_ni: 0.032852255
Data Source: BioPlex
PRM2
Tbio
Novelty: 0.0050028
p_int: 0.961096662
p_ni: 0.038903338
Data Source: BioPlex
PRCC
Tbio
Novelty: 0.00836323
p_int: 0.932522479
p_ni: 0.067477521
Score: 0.25
Data Source: BioPlex,STRINGDB
YTHDF1
Tbio
Novelty: 0.02063275
p_int: 0.931325331
p_ni: 0.068674669
Score: 0.357
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  78.78

PubMed score by year
PubTator Score  48.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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