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Tbio
GTF2A1L
TFIIA-alpha and beta-like factor

Protein Summary
Description
May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403751
  • ENSP00000384597
  • ENSG00000242441
  • ENST00000430487
  • ENSP00000387896

Symbol
  • ALF
  • GTF2A1LF
  • ALF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.61
cellular component
0.6
protein domain
0.58
cell type or tissue
0.49
biological process
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
GTF2A2
Tbio
Novelty:  0.03391028
Score:  0.993
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.958
Data Source:  STRINGDB
GTF2A1
Tchem
Novelty:  0.19577296
Score:  0.868
Data Source:  STRINGDB
TBPL2
Tbio
Novelty:  0.01299173
Score:  0.821
Data Source:  STRINGDB
TBPL1
Tbio
Novelty:  0.02184575
Score:  0.819
Data Source:  STRINGDB
POLR2F
Tbio
Family:  Enzyme
Novelty:  0.03787683
Score:  0.817
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.816
Data Source:  STRINGDB
GTF2F2
Tbio
Novelty:  0.02446629
Score:  0.789
Data Source:  STRINGDB
STON1
Tbio
Novelty:  0.03501188
Score:  0.779
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.761
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
7
9
87.9
waist-hip ratio
3
7
9
87.4
body mass index
3
3
3
81.8
high density lipoprotein cholesterol measurement
2
1
2
76
2
1
0
1.4
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
87.9
waist-hip ratio
9
87.4
body mass index
3
81.8
high density lipoprotein cholesterol measurement
2
76
0
1.4
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 4.44
PubMed score by year
PubTator Score 45.47
PubTator score by year
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Related Publications
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Year
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