Tbio ING4 Inhibitor of growth protein 4

Protein Summary

Description

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UNL4
• A4KYM4
• A4KYM6
• D3DUR8
• Q0EF62
• Q0EF63
• Q4VBQ6
• Q96E15
• Q9H3J0

Gene Name

• ING4

Ensembl ID

• ENST00000341550
• ENSP00000343396
• ENSG00000111653
• ENST00000396807
• ENSP00000380024
• ENST00000412586
• ENSP00000412705
• ENST00000423703
• ENSP00000414008
• ENST00000444704
• ENSP00000397343
• ENST00000446105
• ENSP00000415903

Symbol

• my036
• p29ING4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
kinase perturbation	0.96
histone modification site profile	0.92
transcription factor binding site profile	0.87
biological process	0.81

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Inhibitor Of Growth Protein 4

Protein / Transcription Factor / Transcription Cofactor / Inhibitor Of Growth Protein 4

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Inhibitor Of Growth Protein 4

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Inhibitor Of Growth Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.7   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.7   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0