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Tbio
ING4
Inhibitor of growth protein 4

Protein Summary
Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341550
  • ENSP00000343396
  • ENSG00000111653
  • ENST00000396807
  • ENSP00000380024
  • ENST00000412586
  • ENSP00000412705
  • ENST00000423703
  • ENSP00000414008
  • ENST00000444704
  • ENSP00000397343
  • ENST00000446105
  • ENSP00000415903

Symbol
  • my036
  • p29ING4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
kinase perturbation
0.96
histone modification site profile
0.92
transcription factor binding site profile
0.87
biological process
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.88   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.88   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
2
2
79.2
mean corpuscular volume
1
1
1
57.3
red blood cell distribution width
1
1
1
56.8
triglyceride measurement
1
1
1
53.3
heel bone mineral density
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
79.2
mean corpuscular volume
1
57.3
red blood cell distribution width
1
56.8
triglyceride measurement
1
53.3
heel bone mineral density
2
47.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 4 [Source:HGNC Symbol;Acc:HGNC:19423]
Macaque
inhibitor of growth family member 4
722073
Mouse
MGI:107307
28019
Rat
RGD:1309407
297597
Dog
inhibitor of growth family member 4
477712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibitor of growth family member 4 [Source:HGNC Symbol;Acc:HGNC:19423]
Macaque
inhibitor of growth family member 4
Mouse
Rat
Dog
inhibitor of growth family member 4
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UNL4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
JADE2
Tbio
Family:  Epigenetic
Novelty:  0.19820849
p_int:  0.999999992
p_ni:  4e-9
p_wrong:  5e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999999987
p_ni:  1e-8
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KAT7
Tbio
Family:  TF; Epigenetic
Novelty:  0.01783137
Score:  0.991
Data Source:  Reactome,STRINGDB
JADE3
Tbio
Family:  Epigenetic
Novelty:  0.29964429
Score:  0.977
Data Source:  STRINGDB
JADE1
Tbio
Family:  Epigenetic
Novelty:  0.06758769
Score:  0.971
Data Source:  Reactome,STRINGDB
EPC1
Tbio
Novelty:  0.03216371
Score:  0.821
Data Source:  STRINGDB
EPC2
Tbio
Novelty:  0.02760809
Score:  0.812
Data Source:  STRINGDB
KAT6A
Tchem
Family:  Epigenetic
Novelty:  0.00478771
Score:  0.783
Data Source:  STRINGDB
KAT6B
Tchem
Family:  Epigenetic
Novelty:  0.00361345
Score:  0.777
Data Source:  STRINGDB
BRPF3
Tchem
Family:  Epigenetic
Novelty:  0.14559787
Score:  0.764
Data Source:  STRINGDB
Publication Statistics
PubMed Score  94.88

PubMed score by year
PubTator Score  92.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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