You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SSR3
Translocon-associated protein subunit gamma

Protein Summary
Description
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265044
  • ENSP00000265044
  • ENSG00000114850
  • ENST00000467789
  • ENSP00000420641

Symbol
  • TRAPG
  • TRAPG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
kinase perturbation
0.81
microRNA
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.3   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.3   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
75.3
visceral adipose tissue measurement
1
1
1
17.9
2
1
0
1.2
13.7
body height
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
75.3
visceral adipose tissue measurement
1
17.9
0
1.2
13.7
body height
1
1.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
signal sequence receptor subunit 3
706518
Mouse
MGI:1914687
67437
Dog
signal sequence receptor subunit 3
VGNC:46839
477124
Horse
signal sequence receptor subunit 3
VGNC:23616
100057287
Cow
signal sequence receptor subunit 3
VGNC:35321
767980
Species
Name
OMA
EggNOG
Inparanoid
Macaque
signal sequence receptor subunit 3
Mouse
Dog
signal sequence receptor subunit 3
Horse
signal sequence receptor subunit 3
Cow
signal sequence receptor subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UNL2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (178)
1 – 10 of 178
PCBP4
Tbio
Novelty: 0.03763262
p_int: 0.980872028
p_ni: 0.019127702
p_wrong: 2.7e-7
Data Source: BioPlex
HMGCS2
Tbio
Family: Enzyme
Novelty: 0.0103808
p_int: 0.916191786
p_ni: 0.08377421
p_wrong: 0.000034004
Data Source: BioPlex
APOB
Tchem
Novelty: 0.00008247
p_int: 0.876032728
p_ni: 0.123095459
p_wrong: 0.000871813
Data Source: BioPlex
SSR1
Tbio
Novelty: 0.02009694
Score: 0.999
Data Source: Reactome,STRINGDB
SSR2
Tbio
Novelty: 0.01383689
Score: 0.998
Data Source: Reactome,STRINGDB
SSR4
Tbio
Novelty: 0.04072695
Score: 0.998
Data Source: Reactome,STRINGDB
SEC61B
Tbio
Novelty: 0.08622222
Score: 0.994
Data Source: STRINGDB
DDOST
Tchem
Family: Enzyme
Novelty: 0.01797594
Score: 0.994
Data Source: STRINGDB
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
Score: 0.992
Data Source: STRINGDB
SPCS2
Tdark
Family: Enzyme
Novelty: 0.21358992
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.30

PubMed score by year
PubTator Score  6.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: