You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STX8
Syntaxin-8

Protein Summary
Description
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306357
  • ENSP00000305255
  • ENSG00000170310

Symbol
  • CARB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.91
cellular component
0.9
disease perturbation
0.83
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 427.37   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 427.37   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (128)
1 – 10 of 128
TMEM63C
Tdark
Family: IC
Novelty: 0.01052482
p_int: 0.99998591
p_ni: 0.00001409
Data Source: BioPlex
STX7
Tbio
Novelty: 0.052457
p_int: 0.999955042
p_ni: 0.000044957
Score: 0.996
Data Source: BioPlex,STRINGDB
NAPG
Tbio
Novelty: 0.02021534
p_int: 0.999877887
p_ni: 0.000122113
Score: 0.943
Data Source: BioPlex,STRINGDB
STX18
Tbio
Novelty: 0.03286471
p_int: 0.999778585
p_ni: 0.000221415
Score: 0.938
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.07003045
p_int: 0.999681865
p_ni: 0.000318135
Score: 0.956
Data Source: BioPlex,STRINGDB
FAM9C
Tdark
Novelty: 1.42857143
p_int: 0.999301562
p_ni: 0.000698438
Data Source: BioPlex
SEC22B
Tbio
Novelty: 0.04196763
p_int: 0.999120065
p_ni: 0.000879935
Score: 0.92
Data Source: BioPlex,STRINGDB
VAMP4
Tbio
Novelty: 0.04197927
p_int: 0.998747481
p_ni: 0.001252519
Score: 0.929
Data Source: BioPlex,STRINGDB
DTNBP1
Tbio
Novelty: 0.00371788
p_int: 0.998123306
p_ni: 0.001876694
Score: 0.343
Data Source: BioPlex,STRINGDB
VAMP5
Tbio
Novelty: 0.10775052
p_int: 0.998048122
p_ni: 0.001951878
Score: 0.844
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  427.37

PubMed score by year
PubTator Score  287.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: