Tbio SNX7 Sorting nexin-7

Protein Summary

Description

May be involved in several stages of intracellular trafficking. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q9UNH6
• A8KAF3
• D3DT50
• Q53FQ3
• Q5VT09
• Q5VT10
• Q86U82
• Q8WVD4
• Q96FW9
• Q9Y3Z7

Gene Name

• SNX7

Ensembl ID

• ENST00000306121
• ENSP00000304429
• ENSG00000162627

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
virus perturbation	0.85
interacting protein	0.71
histone modification site profile	0.69
PubMedID	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.39   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.39   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0