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Tbio
CDC14A
Dual specificity protein phosphatase CDC14A

Protein Summary
Description
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336454
  • ENSP00000336739
  • ENSG00000079335
  • ENST00000361544
  • ENSP00000354916
  • ENST00000370124
  • ENSP00000359142
  • ENST00000644813
  • ENSP00000496374

Symbol
  • cdc14
  • DFNB32
  • DFNB35
  • hCDC14
  • DFNB105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
hub protein
0.88
transcription factor binding site profile
0.87
cellular component
0.72
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.72   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.72   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
FZR1
Tbio
Novelty:  0.01599606
Score:  0.989
Data Source:  STRINGDB
MAPK6
Tbio
Family:  Kinase
Novelty:  0.01012514
Score:  0.967
Data Source:  Reactome,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.948
Data Source:  STRINGDB
CCND3
Tchem
Novelty:  0.00223085
Score:  0.934
Data Source:  STRINGDB
CDC14B
Tbio
Family:  Enzyme
Novelty:  0.12492348
Score:  0.904
Data Source:  STRINGDB
ESPL1
Tbio
Family:  Enzyme
Novelty:  0.00346666
Score:  0.877
Data Source:  STRINGDB
WEE1
Tchem
Family:  Kinase
Novelty:  0.00162432
Score:  0.865
Data Source:  STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.865
Data Source:  STRINGDB
INCENP
Tbio
Novelty:  0.00704937
Score:  0.864
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.864
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Reactome
MAPK family signaling cascades
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
Cell Cycle
Cell Cycle, Mitotic
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
MAPK family signaling cascades
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
2
3
5.8
66.8
glucose measurement
1
1
1
40.7
HbA1c measurement
1
1
1
35
serum urea measurement
1
1
1
33.1
monocyte percentage of leukocytes
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
5.8
66.8
glucose measurement
1
40.7
HbA1c measurement
1
35
serum urea measurement
1
33.1
monocyte percentage of leukocytes
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 14A
VGNC:471
457058
Macaque
cell division cycle 14A
716475
Mouse
MGI:2442676
229776
Rat
RGD:1304649
310806
Dog
cell division cycle 14A
VGNC:38986
479926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 14A
Macaque
cell division cycle 14A
Mouse
Rat
Dog
cell division cycle 14A
Publication Statistics
PubMed Score 280.72
PubMed score by year
PubTator Score 81.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title