Tbio TNFSF18 Tumor necrosis factor ligand superfamily member 18

Protein Summary

Description

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UNG2
• A9IQG8
• O95852
• Q6ISV1

Gene Name

• TNFSF18

Ensembl ID

• ENST00000404377
• ENSP00000385470
• ENSG00000120337

Symbol

• AITRL
• GITRL
• TL6
• TL6
• AITRL
• GITRL
• TNLG2A
• hGITRL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.63
cell type or tissue	0.58
tissue sample	0.56
tissue	0.53
biological term	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.86   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 517   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.86   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0