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Tbio
TNFSF18
Tumor necrosis factor ligand superfamily member 18

Protein Summary
Description
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404377
  • ENSP00000385470
  • ENSG00000120337

Symbol
  • AITRL
  • GITRL
  • TL6
  • TL6
  • AITRL
  • GITRL
  • TNLG2A
  • hGITRL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.63
cell type or tissue
0.58
tissue sample
0.56
tissue
0.53
biological term
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.86   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.86   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.999999704
p_ni:  2.96e-7
Data Source:  BioPlex
NRM
Tbio
Novelty:  0.02136368
p_int:  0.999995204
p_ni:  0.000004707
p_wrong:  8.9e-8
Data Source:  BioPlex
SUN1
Tbio
Novelty:  0.00931817
p_int:  0.999974739
p_ni:  0.000025261
Data Source:  BioPlex
MAN2A2
Tbio
Family:  Enzyme
Novelty:  0.07098345
p_int:  0.999959051
p_ni:  0.000040949
Data Source:  BioPlex
MAN1A2
Tbio
Family:  Enzyme
Novelty:  0.15637608
p_int:  0.999912829
p_ni:  0.000087169
p_wrong:  2e-9
Data Source:  BioPlex
PEX13
Tbio
Novelty:  0.01777214
p_int:  0.999867317
p_ni:  0.000110549
p_wrong:  0.000022133
Data Source:  BioPlex
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.999806811
p_ni:  0.000009083
p_wrong:  0.000184106
Data Source:  BioPlex
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
p_int:  0.999680204
p_ni:  0.000319784
p_wrong:  1.2e-8
Data Source:  BioPlex
TMEM120A
Tdark
Novelty:  0.21664358
p_int:  0.999666459
p_ni:  0.000054033
p_wrong:  0.000279508
Data Source:  BioPlex
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
p_int:  0.999622987
p_ni:  0.000375928
p_wrong:  0.000001085
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.2
12.1
response to darapladib
1
1
0
3.2
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.2
12.1
response to darapladib
0
3.2
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TNF superfamily member 18
678654
Mouse
MGI:2673064
240873
Rat
RGD:1305066
364031
Dog
TNF superfamily member 18
VGNC:53841
100855912
Horse
TNF superfamily member 18
VGNC:24378
100060504
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TNF superfamily member 18
Mouse
Rat
Dog
TNF superfamily member 18
Horse
TNF superfamily member 18
Publication Statistics
PubMed Score 91.86
PubMed score by year
PubTator Score 48.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title