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Tbio
MAGED2
Melanoma-associated antigen D2

Protein Summary
Description
Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218439
  • ENSP00000218439
  • ENSG00000102316
  • ENST00000375053
  • ENSP00000364193
  • ENST00000375058
  • ENSP00000364198
  • ENST00000375068
  • ENSP00000364209
  • ENST00000396224
  • ENSP00000379526

Symbol
  • BCG1
  • 11B6
  • BCG1
  • BCG-1
  • HCA10
  • BARTS5
  • MAGE-D2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
kinase perturbation
0.99
transcription factor perturbation
0.98
interacting protein
0.95
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.71   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.71   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
GNAL
Tbio
Novelty:  0.01757098
p_int:  0.999976863
p_ni:  0.000023137
Score:  0.858
Data Source:  BioPlex,STRINGDB
P63092
Tbio
Novelty:  0.00284739
p_int:  0.999870889
p_ni:  0.000129111
Score:  0.876
Data Source:  BioPlex,STRINGDB
RIC8B
Tbio
Novelty:  0.00400481
p_int:  0.99923332
p_ni:  0.00076668
Score:  0.806
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.958136119
p_ni:  0.041863881
Score:  0.499
Data Source:  BioPlex,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.903133829
p_ni:  0.096866171
Data Source:  BioPlex
NAP1L4
Tbio
Novelty:  0.08710866
p_int:  0.825396281
p_ni:  0.174603719
Score:  0.357
Data Source:  BioPlex,STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.906
Data Source:  STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.906
Data Source:  STRINGDB
TGFB3
Tbio
Novelty:  0.00068568
Score:  0.905
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
7.1
mean corpuscular volume
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
7.1
mean corpuscular volume
1
6.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAGE family member D2
VGNC:1357
107971111
Macaque
MAGE family member D2
701719
Mouse
MGI:1933391
80884
Rat
RGD:70899
113947
Dog
MAGE family member D2
VGNC:54170
480934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAGE family member D2
Macaque
MAGE family member D2
Mouse
Rat
Dog
MAGE family member D2
Publication Statistics
PubMed Score 62.71
PubMed score by year
PubTator Score 32.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title