Tbio PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2

Protein Summary

Description

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9UNF0
• O95921
• Q96HV9
• Q9H0D3
• Q9NPN1
• Q9Y4V2

Gene Name

• PACSIN2

Ensembl ID

• ENST00000263246
• ENSP00000263246
• ENSG00000100266
• ENST00000337959
• ENSP00000338379
• ENST00000402229
• ENSP00000385040
• ENST00000403744
• ENSP00000385372
• ENST00000407585
• ENSP00000385952

Symbol

• SDPII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.79
transcription factor perturbation	0.74
interacting protein	0.73
transcription factor	0.7
cell type or tissue	0.67

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.79   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.79   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (3)

Reactome (3)

Clathrin-mediated endocytosis (R-HSA-8856828)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (32)

Functions (6)

Components (16)

Processes (10)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
phosphatidic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
cytoskeletal protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phospholipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transporter activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (166)

Explore Interacting Targets

1 – 10 of 166

• See Interactions on String-DB

COBL

Tbio

Novelty: 0.03002386

p_int: 1

Score: 0.908

Data Source: BioPlex,STRINGDB

PACSIN3

Tbio

Family: Enzyme

Novelty: 0.17960231

p_int: 0.999999996

p_ni: 4e-9

Score: 0.985

Data Source: BioPlex,STRINGDB

COBLL1

Tbio

Novelty: 0.1137875

p_int: 0.999999994

p_ni: 6e-9

Score: 0.858

Data Source: BioPlex,STRINGDB

PACSIN1

Tbio

Family: Enzyme

Novelty: 0.01829056

p_int: 0.999999019

p_ni: 9.81e-7

Score: 0.982

Data Source: BioPlex,STRINGDB

THG1L

Tbio

Family: Enzyme

Novelty: 0.18828452

p_int: 0.999997189

p_ni: 3.2e-7

p_wrong: 0.000002491

Score: 0.534

Data Source: BioPlex,STRINGDB

MPRIP

Tbio

Family: Enzyme

Novelty: 0.06222313

p_int: 0.999737352

p_ni: 0.000262647

Score: 0.527

Data Source: BioPlex,STRINGDB

WIPF2

Tbio

Novelty: 0.00894312

p_int: 0.9956836

p_ni: 0.002590812

p_wrong: 0.001725588

Score: 0.543

Data Source: BioPlex,STRINGDB

RAI14

Tbio

Novelty: 0.04274502

p_int: 0.817135383

p_ni: 0.182864615

p_wrong: 2e-9

Score: 0.69

Data Source: BioPlex,STRINGDB

GTF2E2

Tbio

Novelty: 0.16730745

p_int: 0.792215404

p_ni: 0.207784596

Data Source: BioPlex

DNM2

Tchem

Novelty: 0.00331333

Score: 0.973

Data Source: STRINGDB

Publication Statistics

PubMed Score  27.79

PubMed score by year

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PubTator Score  26.52

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Alternative splicing
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton

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mean platelet volume
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