Tbio PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2

Protein Summary

Description

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9UNF0
• O95921
• Q96HV9
• Q9H0D3
• Q9NPN1
• Q9Y4V2

Gene Name

• PACSIN2

Ensembl ID

• ENST00000263246
• ENSP00000263246
• ENSG00000100266
• ENST00000337959
• ENSP00000338379
• ENST00000402229
• ENSP00000385040
• ENST00000403744
• ENSP00000385372
• ENST00000407585
• ENSP00000385952

Symbol

• SDPII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.79
transcription factor perturbation	0.74
interacting protein	0.73
transcription factor	0.7
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.78   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.78   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (166)

Explore Interacting Targets

1 – 10 of 166

• See Interactions on String-DB

COBL

Tbio

Novelty:  0.01903038

p_int:  1

Score:  0.908

Data Source:  BioPlex,STRINGDB

PACSIN3

Tbio

Family:  Enzyme

Novelty:  0.11715903

p_int:  0.999999996

p_ni:  4e-9

Score:  0.985

Data Source:  BioPlex,STRINGDB

COBLL1

Tbio

Novelty:  0.09264701

p_int:  0.999999994

p_ni:  6e-9

Score:  0.858

Data Source:  BioPlex,STRINGDB

PACSIN1

Tbio

Family:  Enzyme

Novelty:  0.01482925

p_int:  0.999999019

p_ni:  9.81e-7

Score:  0.982

Data Source:  BioPlex,STRINGDB

THG1L

Tbio

Family:  Enzyme

Novelty:  0.17339179

p_int:  0.999997189

p_ni:  3.2e-7

p_wrong:  0.000002491

Score:  0.534

Data Source:  BioPlex,STRINGDB

MPRIP

Tbio

Family:  Enzyme

Novelty:  0.03253403

p_int:  0.999737352

p_ni:  0.000262647

Score:  0.527

Data Source:  BioPlex,STRINGDB

WIPF2

Tbio

Novelty:  0.11973409

p_int:  0.9956836

p_ni:  0.002590812

p_wrong:  0.001725588

Score:  0.543

Data Source:  BioPlex,STRINGDB

RAI14

Tbio

Novelty:  0.06291577

p_int:  0.817135383

p_ni:  0.182864615

p_wrong:  2e-9

Score:  0.69

Data Source:  BioPlex,STRINGDB

GTF2E2

Tbio

Novelty:  0.18033153

p_int:  0.792215404

p_ni:  0.207784596

Data Source:  BioPlex

DNM2

Tchem

Novelty:  0.00265965

Score:  0.973

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Clathrin-mediated endocytosis (R-HSA-8856828)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (32)

Functions (6)

Components (16)

Processes (10)

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1 – 6 of 6

GO Term	Evidence	Assigned by
phosphatidic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
cytoskeletal protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phospholipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transporter activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (9)

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1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	4	5	5		98.8
platelet count	EFO_0004309	2	3	3		94.5
cancer	EFO_0000311	1	2	0	1.2	71.8
prostate carcinoma	EFO_0001663	7	1	0	1.1	42.1
HbA1c measurement	EFO_0004541	2	2	2		40.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	5		98.8
platelet count	EFO_0004309	3		94.5
cancer	EFO_0000311	0	1.2	71.8
prostate carcinoma	EFO_0001663	0	1.1	42.1
HbA1c measurement	EFO_0004541	2		40.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
cancer
HbA1c measurement
high density lipoprotein cholesterol measurement
mean platelet volume
platelet count
prostate carcinoma
red blood cell distribution width
reticulocyte count
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	protein kinase C and casein kinase substrate in neurons 2	VGNC:5290	470231
Macaque	protein kinase C and casein kinase substrate in neurons 2		711242
Mouse	protein kinase C and casein kinase substrate in neurons 2	MGI:1345153	23970
Rat	protein kinase C and casein kinase substrate in neurons 2	RGD:69411	124461
Dog	protein kinase C and casein kinase substrate in neurons 2	VGNC:44232	100683200

Species	Name	OMA	EggNOG	Inparanoid
Chimp	protein kinase C and casein kinase substrate in neurons 2
Macaque	protein kinase C and casein kinase substrate in neurons 2
Mouse	protein kinase C and casein kinase substrate in neurons 2
Rat	protein kinase C and casein kinase substrate in neurons 2
Dog	protein kinase C and casein kinase substrate in neurons 2

Publication Statistics

PubMed Score 43.78

PubMed score by year

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PubTator Score 26.52

PubTator score by year

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Related Publications

Text Mined References (49)

GeneRif Annotations (22)

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PMID	Year	Title