You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PACSIN2
Protein kinase C and casein kinase substrate in neurons protein 2

Protein Summary
Description
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263246
  • ENSP00000263246
  • ENSG00000100266
  • ENST00000337959
  • ENSP00000338379
  • ENST00000402229
  • ENSP00000385040
  • ENST00000403744
  • ENSP00000385372
  • ENST00000407585
  • ENSP00000385952

Symbol
  • SDPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
transcription factor perturbation
0.74
interacting protein
0.73
transcription factor
0.7
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.78   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.78   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
COBL
Tbio
Novelty:  0.01903038
p_int:  1
Score:  0.908
Data Source:  BioPlex,STRINGDB
PACSIN3
Tbio
Family:  Enzyme
Novelty:  0.11715903
p_int:  0.999999996
p_ni:  4e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
COBLL1
Tbio
Novelty:  0.09264701
p_int:  0.999999994
p_ni:  6e-9
Score:  0.858
Data Source:  BioPlex,STRINGDB
PACSIN1
Tbio
Family:  Enzyme
Novelty:  0.01482925
p_int:  0.999999019
p_ni:  9.81e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
THG1L
Tbio
Family:  Enzyme
Novelty:  0.17339179
p_int:  0.999997189
p_ni:  3.2e-7
p_wrong:  0.000002491
Score:  0.534
Data Source:  BioPlex,STRINGDB
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
p_int:  0.999737352
p_ni:  0.000262647
Score:  0.527
Data Source:  BioPlex,STRINGDB
WIPF2
Tbio
Novelty:  0.11973409
p_int:  0.9956836
p_ni:  0.002590812
p_wrong:  0.001725588
Score:  0.543
Data Source:  BioPlex,STRINGDB
RAI14
Tbio
Novelty:  0.06291577
p_int:  0.817135383
p_ni:  0.182864615
p_wrong:  2e-9
Score:  0.69
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.792215404
p_ni:  0.207784596
Data Source:  BioPlex
DNM2
Tchem
Novelty:  0.00265965
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
5
5
98.8
platelet count
2
3
3
94.5
1
2
0
1.2
71.8
7
1
0
1.1
42.1
HbA1c measurement
2
2
2
40.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
98.8
platelet count
3
94.5
0
1.2
71.8
0
1.1
42.1
HbA1c measurement
2
40.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C and casein kinase substrate in neurons 2
VGNC:5290
470231
Macaque
protein kinase C and casein kinase substrate in neurons 2
711242
Mouse
MGI:1345153
23970
Rat
RGD:69411
124461
Dog
protein kinase C and casein kinase substrate in neurons 2
VGNC:44232
100683200
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C and casein kinase substrate in neurons 2
Macaque
protein kinase C and casein kinase substrate in neurons 2
Mouse
Rat
Dog
protein kinase C and casein kinase substrate in neurons 2
Publication Statistics
PubMed Score 43.78
PubMed score by year
PubTator Score 26.52
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title