You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STUB1
E3 ubiquitin-protein ligase CHIP

Protein Summary
Description
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-cha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219548
  • ENSP00000219548
  • ENSG00000103266
  • ENST00000564370
  • ENSP00000456875
  • ENST00000565677
  • ENSP00000457228

Symbol
  • CHIP
  • CHIP
  • SCA48
  • UBOX1
  • SCAR16
  • HSPABP2
  • NY-CO-7
  • SDCCAG7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.98
kinase perturbation
0.97
biological process
0.92
molecular function
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1710.94   (req: < 5)
Gene RIFs: 153   (req: <= 3)
Antibodies: 431   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1710.94   (req: >= 5)
Gene RIFs: 153   (req: > 3)
Antibodies: 431   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STIP1 homology and U-box containing protein 1
VGNC:9146
453803
Mouse
MGI:1891731
56424
Rat
RGD:1306167
287155
Dog
STIP1 homology and U-box containing protein 1
VGNC:54073
479892
Horse
STIP1 homology and U-box containing protein 1
VGNC:51250
100066999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STIP1 homology and U-box containing protein 1
Mouse
Rat
Dog
STIP1 homology and U-box containing protein 1
Horse
STIP1 homology and U-box containing protein 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Downregulation of ERBB2 signaling
Reactome
Downregulation of TGF-beta receptor signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Downregulation of ERBB2 signaling
Downregulation of TGF-beta receptor signaling
Gene Ontology Terms (52)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (522)
1 – 10 of 522
KLHL34
Tdark
Novelty: 2.18471039
p_int: 0.987572256
p_ni: 0.012427744
Score: 0.196
Data Source: BioPlex,STRINGDB
SLC27A3
Tbio
Family: Transporter
Novelty: 0.1037612
p_int: 0.954615365
p_ni: 0.045384635
Score: 0.185
Data Source: BioPlex,STRINGDB
ABHD15
Tdark
Family: Enzyme
Novelty: 1.53507944
p_int: 0.949212892
p_ni: 0.050787108
Score: 0.188
Data Source: BioPlex,STRINGDB
TCAP
Tbio
Novelty: 0.00623581
p_int: 0.910884525
p_ni: 0.089115475
Score: 0.238
Data Source: BioPlex,STRINGDB
NAT16
Tdark
Family: Enzyme
Novelty: 0.69697274
p_int: 0.8718986
p_ni: 0.1281014
Score: 0.187
Data Source: BioPlex,STRINGDB
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.86868421
p_ni: 0.13131579
Data Source: BioPlex
TYSND1
Tbio
Family: Enzyme
Novelty: 0.16036122
p_int: 0.85422518
p_ni: 0.14577482
Score: 0.232
Data Source: BioPlex,STRINGDB
KHDC1
Tbio
Novelty: 0.13778027
p_int: 0.800276459
p_ni: 0.199723541
Data Source: BioPlex
KCND2
Tclin
Family: IC
Novelty: 0.00297203
p_int: 0.781907182
p_ni: 0.218092818
Score: 0.206
Data Source: BioPlex,STRINGDB
KLHDC2
Tbio
Novelty: 0.01485159
p_int: 0.768871876
p_ni: 0.231128124
Data Source: BioPlex
Publication Statistics
PubMed Score  1710.94

PubMed score by year
PubTator Score  33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: