You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EDAR
Tumor necrosis factor receptor superfamily member EDAR

Protein Summary
Description
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258443
  • ENSP00000258443
  • ENSG00000135960
  • ENST00000376651
  • ENSP00000365839
  • ENST00000409271
  • ENSP00000386371

Symbol
  • DL
  • DL
  • ED3
  • ED5
  • ED1R
  • EDA3
  • HRM1
  • EDA1R
  • ECTD10A
  • ECTD10B
  • EDA-A1R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.64
microRNA
0.63
gene perturbation
0.62
phenotype
0.61
biological process
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.58   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.58   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
EDARADD
Tbio
Novelty:  0.02153414
Score:  0.992
Data Source:  Reactome,STRINGDB
EDA
Tbio
Novelty:  0.00352464
Score:  0.99
Data Source:  Reactome,STRINGDB
SHH
Tchem
Novelty:  0.00028347
Score:  0.743
Data Source:  STRINGDB
SLC24A5
Tbio
Family:  Transporter
Novelty:  0.01224635
Score:  0.728
Data Source:  STRINGDB
WNT10B
Tbio
Novelty:  0.00503163
Score:  0.678
Data Source:  STRINGDB
PAX9
Tbio
Family:  TF
Novelty:  0.00581813
Score:  0.655
Data Source:  STRINGDB
SLC45A2
Tbio
Family:  Transporter
Novelty:  0.00268252
Score:  0.648
Data Source:  STRINGDB
WNT10A
Tbio
Novelty:  0.00641352
Score:  0.637
Data Source:  STRINGDB
CYLD
Tbio
Family:  Enzyme
Novelty:  0.00215465
Score:  0.626
Data Source:  STRINGDB
UNC119
Tchem
Novelty:  0.00396292
Score:  0.626
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair morphology measurement
1
1
0
3.3
87.3
balding measurement
1
1
1
66
synophrys measurement
1
1
1
64.4
lobe size
1
1
1
55.2
helix rolling
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair morphology measurement
0
3.3
87.3
balding measurement
1
66
synophrys measurement
1
64.4
lobe size
1
55.2
helix rolling
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ectodysplasin A receptor
695059
Mouse
MGI:1343498
13608
Rat
RGD:1561714
365581
Dog
ectodysplasin A receptor
VGNC:40190
481305
Horse
ectodysplasin A receptor
VGNC:51297
100060614
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ectodysplasin A receptor
Mouse
Rat
Dog
ectodysplasin A receptor
Horse
ectodysplasin A receptor
Publication Statistics
PubMed Score 243.58
PubMed score by year
PubTator Score 123.29
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Text