EDAR
Tumor necrosis factor receptor superfamily member EDAR
Protein Summary
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
- ENST00000258443
- ENSP00000258443
- ENSG00000135960
- ENST00000376651
- ENSP00000365839
- ENST00000409271
- ENSP00000386371
- DL
- DL
- ED3
- ED5
- ED1R
- EDA3
- HRM1
- EDA1R
- ECTD10A
- ECTD10B
- EDA-A1R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.64 | ||
microRNA | 0.63 | ||
gene perturbation | 0.62 | ||
phenotype | 0.61 | ||
biological process | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.58 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 289 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.58 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 289 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (57)
Nearest Tclin Targets
Pathways (8)
Reactome (4)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Reactome | TNFs bind their physiological receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNFR2 non-canonical NF-kB pathway | ||||
TNFs bind their physiological receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (3)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hair morphology measurement | 1 | 1 | 0 | 3.3 | 87.3 | ||||
balding measurement | 1 | 1 | 1 | 66 | |||||
synophrys measurement | 1 | 1 | 1 | 64.4 | |||||
lobe size | 1 | 1 | 1 | 55.2 | |||||
helix rolling | 1 | 1 | 1 | 55.2 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hair morphology measurement | 0 | 3.3 | 87.3 | ||||
balding measurement | 1 | 66 | |||||
synophrys measurement | 1 | 64.4 | |||||
lobe size | 1 | 55.2 | |||||
helix rolling | 1 | 55.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ectodysplasin A receptor | 695059 | ||||||
Mouse | MGI:1343498 | 13608 | ||||||
Rat | RGD:1561714 | 365581 | ||||||
Dog | ectodysplasin A receptor | VGNC:40190 | 481305 | |||||
Horse | ectodysplasin A receptor | VGNC:51297 | 100060614 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ectodysplasin A receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | ectodysplasin A receptor | |||||
Horse | ectodysplasin A receptor | |||||
Publication Statistics
PubMed Score 243.58
PubMed score by year
PubTator Score 123.29
PubTator score by year
Related Publications
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Text |
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