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Tbio
A4GNT
Alpha-1,4-N-acetylglucosaminyltransferase

Protein Summary
Description
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity). This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236709
  • ENSP00000236709
  • ENSG00000118017

Symbol
  • alpha4GnT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.62
tissue
0.51
cell line
0.47
gene perturbation
0.46
transcription factor
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-1,4-N-acetylglucosaminyltransferase
VGNC:1725
460724
Mouse
MGI:2143261
333424
Rat
RGD:1590210
685758
Dog
alpha-1,4-N-acetylglucosaminyltransferase
VGNC:37401
485683
Horse
alpha-1,4-N-acetylglucosaminyltransferase
VGNC:14883
100033872
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-1,4-N-acetylglucosaminyltransferase
Mouse
Rat
Dog
alpha-1,4-N-acetylglucosaminyltransferase
Horse
alpha-1,4-N-acetylglucosaminyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UNA3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (60)
1 – 10 of 60
FANK1
Tbio
Novelty: 0.12389783
p_int: 0.999980804
p_ni: 0.00000596
p_wrong: 0.000013236
Score: 0.237
Data Source: BioPlex,STRINGDB
JMJD8
Tbio
Novelty: 0.31175159
p_int: 0.9997938
p_ni: 0.000206196
p_wrong: 4e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
ICK
Tchem
Family: Kinase
Novelty: 0.00810476
p_int: 0.967140651
p_ni: 0.001110951
p_wrong: 0.031748397
Score: 0.179
Data Source: BioPlex,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.964517417
p_ni: 0.035482583
Data Source: BioPlex
RNF167
Tbio
Family: Enzyme
Novelty: 0.14270182
p_int: 0.955349289
p_ni: 0.031201942
p_wrong: 0.013448769
Score: 0.189
Data Source: BioPlex,STRINGDB
PRXL2A
Tchem
Novelty: 0.01336664
p_int: 0.946351336
p_ni: 0.053648664
Score: 0.191
Data Source: BioPlex,STRINGDB
FAM3C
Tbio
Novelty: 0.04598347
p_int: 0.890424217
p_ni: 0.109479689
p_wrong: 0.000096094
Score: 0.177
Data Source: BioPlex,STRINGDB
FAM69A
Tdark
Novelty: 0.35978059
p_int: 0.825958205
p_ni: 0.174041624
p_wrong: 1.71e-7
Score: 0.152
Data Source: BioPlex,STRINGDB
IMPA2
Tbio
Family: Enzyme
Novelty: 0.03983031
p_int: 0.812221957
p_ni: 0.012698722
p_wrong: 0.175079321
Score: 0.187
Data Source: BioPlex,STRINGDB
ABHD14A
Tdark
Family: Enzyme
Novelty: 0.77988335
p_int: 0.788354856
p_ni: 0.21164514
p_wrong: 4e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.83

PubMed score by year
PubTator Score  6.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer