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Tbio
ARHGAP26
Rho GTPase-activating protein 26

Protein Summary
Description
GTPase-activating protein for RHOA and CDC42. Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274498
  • ENSP00000274498
  • ENSG00000145819
  • ENST00000378004
  • ENSP00000367243
  • ENST00000645722
  • ENSP00000495131

Symbol
  • GRAF
  • KIAA0621
  • OPHN1L
  • GRAF
  • GRAF1
  • OPHN1L
  • OPHN1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.92
transcription factor binding site profile
0.88
histone modification site profile
0.86
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.91   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.91   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
95.2
eosinophil count
2
4
4
79.4
3
1
3
66.5
testosterone measurement
1
1
1
60.4
hemoglobin measurement
2
2
2
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
95.2
eosinophil count
4
79.4
3
66.5
testosterone measurement
1
60.4
hemoglobin measurement
2
58.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 26
VGNC:3903
462160
Macaque
Rho GTPase activating protein 26
706084
Mouse
MGI:1918552
71302
Rat
RGD:1310923
307459
Dog
Rho GTPase activating protein 26
VGNC:38054
478046
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 26
Macaque
Rho GTPase activating protein 26
Mouse
Rat
Dog
Rho GTPase activating protein 26
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UNA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (86)
1 – 10 of 86
ARHGAP42
Tbio
Family: Enzyme
Novelty: 0.19934281
p_int: 0.999999978
p_ni: 1e-8
p_wrong: 1.2e-8
Score: 0.314
Data Source: BioPlex,STRINGDB
OPHN1
Tbio
Novelty: 0.0147527
p_int: 0.999999977
p_ni: 2e-9
p_wrong: 2.1e-8
Score: 0.533
Data Source: BioPlex,STRINGDB
ARHGAP10
Tbio
Family: Enzyme
Novelty: 0.22403346
p_int: 0.999999935
p_ni: 2e-9
p_wrong: 6.3e-8
Score: 0.836
Data Source: BioPlex,STRINGDB
C2CD2
Tdark
Novelty: 0.34079266
p_int: 0.999999907
p_ni: 9.1e-8
p_wrong: 2e-9
Score: 0.826
Data Source: BioPlex,STRINGDB
MICAL1
Tbio
Family: Enzyme
Novelty: 0.02668048
p_int: 0.999971009
p_ni: 0.00002899
Score: 0.317
Data Source: BioPlex,STRINGDB
JPH1
Tbio
Novelty: 0.00931679
p_int: 0.999954778
p_ni: 0.000045222
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
RAB11FIP5
Tbio
Novelty: 0.0264203
p_int: 0.999892347
p_ni: 0.000107653
Score: 0.378
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.963
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.962
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.91

PubMed score by year
PubTator Score  388.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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