You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GABRQ
Gamma-aminobutyric acid receptor subunit theta

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000598523
  • ENSP00000469332
  • ENSG00000268089

Symbol
  • THETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.88
protein domain
0.85
cellular component
0.76
cell type or tissue
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.04   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.04   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Approved Drugs (10)
1 – 10 of 10
halothane
chemical structure image
isoflurane
chemical structure image
desflurane
chemical structure image
sevoflurane
chemical structure image
methoxyflurane
chemical structure image
metharbital
chemical structure image
talbutal
chemical structure image
triclofos
chemical structure image
thiamylal
chemical structure image
halazepam
chemical structure image
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor theta subunit
VGNC:7631
107966421
Mouse
MGI:1888498
57249
Rat
RGD:68331
65187
Dog
gamma-aminobutyric acid type A receptor theta subunit
VGNC:41066
492225
Cow
gamma-aminobutyric acid type A receptor theta subunit
VGNC:29202
527180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor theta subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor theta subunit
Cow
gamma-aminobutyric acid type A receptor theta subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UN88-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (85)
1 – 10 of 85
GABRA3
Tclin
Family: IC
Novelty: 0.02180091
Score: 0.951
Data Source: STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.941
Data Source: Reactome,STRINGDB
GABRA4
Tclin
Family: IC
Novelty: 0.03089903
Score: 0.94
Data Source: STRINGDB
GABRA2
Tclin
Family: IC
Novelty: 0.00663529
Score: 0.94
Data Source: STRINGDB
GABRA5
Tclin
Family: IC
Novelty: 0.01499706
Score: 0.94
Data Source: STRINGDB
GABRA1
Tclin
Family: IC
Novelty: 0.0094079
Score: 0.939
Data Source: Reactome,STRINGDB
GABRG3
Tclin
Family: IC
Novelty: 0.0420649
Score: 0.938
Data Source: Reactome,STRINGDB
GABRA6
Tclin
Family: IC
Novelty: 0.02894664
Score: 0.936
Data Source: STRINGDB
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
Score: 0.908
Data Source: Reactome,STRINGDB
GABRB1
Tclin
Family: IC
Novelty: 0.02895574
Score: 0.907
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  9.04

PubMed score by year
PubTator Score  3.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer