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Tbio
G3BP2
Ras GTPase-activating protein-binding protein 2

Protein Summary
Description
Probable scaffold protein that may be involved in mRNA transport.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357854
  • ENSP00000350518
  • ENSG00000138757
  • ENST00000359707
  • ENSP00000352738
  • ENST00000395719
  • ENSP00000379069

Symbol
  • KIAA0660
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.98
ligand (protein) perturbation
0.96
disease perturbation
0.95
co-expressed gene
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.1   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.1   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
USP10
Tchem
Family:  Enzyme
Novelty:  0.05830541
p_int:  0.999984529
p_ni:  0.000015471
Score:  0.983
Data Source:  BioPlex,STRINGDB
NUFIP2
Tbio
Novelty:  0.09366649
p_int:  0.999982888
p_ni:  0.000017112
Score:  0.827
Data Source:  BioPlex,STRINGDB
NUP214
Tbio
Novelty:  0.00924336
p_int:  0.991794216
p_ni:  0.008205784
Score:  0.829
Data Source:  BioPlex,STRINGDB
ATXN2L
Tbio
Novelty:  0.01996982
p_int:  0.978818471
p_ni:  0.021181529
Score:  0.915
Data Source:  BioPlex,STRINGDB
TRIM25
Tbio
Family:  Enzyme
Novelty:  0.0045864
p_int:  0.926957766
p_ni:  0.07299499
p_wrong:  0.000047244
Score:  0.475
Data Source:  BioPlex,STRINGDB
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.91439487
p_ni:  0.08560513
Data Source:  BioPlex
G3BP1
Tbio
Family:  Enzyme
Novelty:  0.00589987
p_int:  0.910457918
p_ni:  0.089542082
Score:  0.846
Data Source:  BioPlex,STRINGDB
POM121
Tbio
Novelty:  0.01691523
p_int:  0.876379233
p_ni:  0.123620767
Score:  0.179
Data Source:  BioPlex,STRINGDB
NUP153
Tbio
Novelty:  0.00696568
p_int:  0.838680456
p_ni:  0.161319544
Score:  0.382
Data Source:  BioPlex,STRINGDB
NUP88
Tbio
Novelty:  0.02483503
p_int:  0.812318834
p_ni:  0.187681166
Score:  0.774
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
49.5
2
2
2
49.4
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
49.5
2
49.4
high density lipoprotein cholesterol measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G3BP stress granule assembly factor 2
VGNC:8263
461244
Mouse
MGI:2442040
23881
Rat
RGD:1309571
305240
Dog
G3BP stress granule assembly factor 2
VGNC:41039
478429
Horse
G3BP stress granule assembly factor 2
VGNC:18179
100050765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G3BP stress granule assembly factor 2
Mouse
Rat
Dog
G3BP stress granule assembly factor 2
Horse
G3BP stress granule assembly factor 2
Publication Statistics
PubMed Score 20.10
PubMed score by year
PubTator Score 11.82
PubTator score by year
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Related Publications
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PMID
Year
Title