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Tchem
SLC6A14
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Protein Summary
Description
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000598581
  • ENSP00000470801
  • ENSG00000268104

Symbol
  • BMIQ11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
molecular function
0.79
small molecule perturbation
0.64
virus perturbation
0.64
cell type or tissue
0.61


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.97   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.97   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 14
VGNC:13501
742654
Macaque
solute carrier family 6 member 14
709598
Mouse
MGI:1890216
56774
Rat
RGD:1561810
298340
Dog
solute carrier family 6 member 14
VGNC:46457
492085
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 14
Macaque
solute carrier family 6 member 14
Mouse
Rat
Dog
solute carrier family 6 member 14
Pathways (12)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Disease
Disorders of transmembrane transporters
Na+/Cl- dependent neurotransmitter transporters
SLC transporter disorders
Protein-Protein Interactions (58)
1 – 10 of 58
SLC9A3
Tclin
Family: Transporter
Novelty: 0.00146466
Score: 0.719
Data Source: STRINGDB
C3orf58
Tbio
Novelty: 0.03694539
Score: 0.681
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.677
Data Source: STRINGDB
SLC36A1
Tchem
Family: Transporter
Novelty: 0.03100896
Score: 0.657
Data Source: STRINGDB
FFAR4
Tchem
Family: GPCR
Novelty: 0.00439747
Score: 0.641
Data Source: STRINGDB
SLC26A9
Tbio
Family: Transporter
Novelty: 0.0354738
Score: 0.636
Data Source: STRINGDB
SLC7A6
Tbio
Family: Transporter
Novelty: 0.02732334
Score: 0.618
Data Source: STRINGDB
SLC1A5
Tchem
Family: Transporter
Novelty: 0.00201741
Score: 0.606
Data Source: STRINGDB
SLC3A1
Tbio
Family: Transporter
Novelty: 0.003328
Score: 0.606
Data Source: STRINGDB
SLC7A8
Tbio
Family: Transporter
Novelty: 0.03433454
Score: 0.602
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.97

PubMed score by year
PubTator Score  24.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer