Protein Summary
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critica ...more
- ENST00000378126
- ENSP00000367366
- ENSG00000081842
- ENST00000527624
- ENSP00000434113
- ENST00000529310
- ENSP00000433378
- CNRS2
- CNR2
- CNRN2
- CNRS2
- CRNR2
- PCDH-ALPHA6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.7 | ||
tissue sample | 0.65 | ||
protein domain | 0.58 | ||
small molecule perturbation | 0.51 | ||
cell line | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.21 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 211 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.21 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 211 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (4)
PCDHA3
Novelty: 0.8622898
p_int: 0.999999999
p_ni: 1e-9
Score: 0.783
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 2 | 1 | 1.1 | 46 | |||||
intelligence | 2 | 2 | 1 | 5.5 | 44 | ||||
1 | 1 | 0 | 6 | 35 | |||||
sum of basophil and neutrophil counts | 1 | 1 | 1 | 30.2 | |||||
neutrophil count | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.1 | 46 | |||||
intelligence | 1 | 5.5 | 44 | ||||
0 | 6 | 35 | |||||
sum of basophil and neutrophil counts | 1 | 30.2 | |||||
neutrophil count | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 2.21
PubMed score by year
PubTator Score 1.24
PubTator score by year
Related Publications
Text Mined References (14)
Items per page:
0 of 0
PMID | Year | Title |
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