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Tbio
PCDHA7
Protocadherin alpha-7

Protein Summary
Description
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are inte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356878
  • ENSP00000349344
  • ENSG00000204963
  • ENST00000525929
  • ENSP00000436426

Symbol
  • CNRS4
  • CNR4
  • CNRN4
  • CNRS4
  • CRNR4
  • PCDH-ALPHA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.93
cell line
0.64
protein domain
0.58
tissue sample
0.58
protein complex
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.13   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.13   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sum of basophil and neutrophil counts
1
1
1
13.9
neutrophil count
1
1
1
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sum of basophil and neutrophil counts
1
13.9
neutrophil count
1
13.9
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Pig
protocadherin alpha-7
102160218
Species
Name
OMA
EggNOG
Inparanoid
Pig
protocadherin alpha-7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UN72-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (12)
1 – 10 of 12
PCDHA9
Tdark
Novelty: 0.30110565
p_int: 1
Score: 0.901
Data Source: BioPlex,STRINGDB
PCDHA10
Tdark
Novelty: 0.73702568
p_int: 1
Score: 0.828
Data Source: BioPlex,STRINGDB
PCDHA8
Tdark
Novelty: 0.57189179
p_int: 0.999999997
p_ni: 3e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
PCDHA4
Tdark
Novelty: 0.30511211
p_int: 0.999999994
p_ni: 6e-9
Score: 0.828
Data Source: BioPlex,STRINGDB
TEX13B
Tdark
Novelty: 2.05061648
Score: 0.555
Data Source: STRINGDB
TCHHL1
Tdark
Novelty: 0.21799821
Score: 0.528
Data Source: STRINGDB
RNF220
Tbio
Family: Enzyme
Novelty: 0.14024436
Score: 0.527
Data Source: STRINGDB
VPS13C
Tbio
Novelty: 0.05207291
Score: 0.508
Data Source: STRINGDB
ZSCAN23
Tdark
Family: TF
Novelty: 1.33288135
Score: 0.454
Data Source: STRINGDB
ADRA1A
Tclin
Family: GPCR
Novelty: 0.00379919
Score: 0.441
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.13

PubMed score by year
PubTator Score  5.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer