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Tdark
PCDHGB4
Protocadherin gamma-B4

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000519479
  • ENSP00000428288
  • ENSG00000253953
  • ENST00000615384
  • ENSP00000484560

Symbol
  • CDH20
  • FIB2
  • FIB2
  • CDH20
  • PCDH-GAMMA-B4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
tissue sample
0.66
protein domain
0.58
cell line
0.48
pathway
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.35   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.35   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
79.6
self reported educational attainment
1
1
1
69.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
79.6
self reported educational attainment
1
69.7
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Pig
protocadherin gamma-B4-like
106509590
Species
Name
OMA
EggNOG
Inparanoid
Pig
protocadherin gamma-B4-like
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (69)
1 – 10 of 69
PCDHGB5
Tdark
Novelty: 4.39427151
p_int: 1
Score: 0.634
Data Source: BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.266
Data Source: BioPlex,STRINGDB
PCDHGB3
Tdark
Novelty: 1.9379995
p_int: 0.99999998
p_ni: 2e-8
Score: 0.586
Data Source: BioPlex,STRINGDB
PCDHGB2
Tdark
Novelty: 1.16587709
p_int: 0.99999998
p_ni: 4e-9
p_wrong: 1.7e-8
Data Source: BioPlex
GRAMD1B
Tbio
Novelty: 0.2994102
p_int: 0.999705759
p_ni: 0.000294201
p_wrong: 4e-8
Data Source: BioPlex
GRAMD1A
Tbio
Novelty: 0.15461113
p_int: 0.999309207
p_ni: 0.000690793
Data Source: BioPlex
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
p_int: 0.999233509
p_ni: 0.000766491
Data Source: BioPlex
EMILIN2
Tbio
Novelty: 0.2816786
p_int: 0.998748427
p_ni: 0.001247986
p_wrong: 0.000003588
Data Source: BioPlex
AREL1
Tdark
Family: Enzyme
Novelty: 0.31082841
p_int: 0.998673702
p_ni: 0.000736843
p_wrong: 0.000589454
Score: 0.152
Data Source: BioPlex,STRINGDB
PCDH10
Tbio
Novelty: 0.01058382
p_int: 0.998439769
p_ni: 0.001560189
p_wrong: 4.2e-8
Score: 0.184
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.35

PubMed score by year
PubTator Score  7.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer