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Tdark
ATP1B4
Protein ATP1B4

Protein Summary
Description
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218008
  • ENSP00000218008
  • ENSG00000101892
  • ENST00000361319
  • ENSP00000355346
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
gene perturbation
0.61
virus perturbation
0.59
tissue
0.55
cellular component
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting family member beta 4
VGNC:12193
738390
Macaque
ATPase Na+/K+ transporting family member beta 4
696160
Mouse
MGI:1915071
67821
Rat
RGD:620994
84396
Dog
ATPase Na+/K+ transporting family member beta 4
VGNC:38251
481036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting family member beta 4
Macaque
ATPase Na+/K+ transporting family member beta 4
Mouse
Rat
Dog
ATPase Na+/K+ transporting family member beta 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UN42-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Signal Transduction
Protein-Protein Interactions (70)
1 – 10 of 70
ATP1A4
Tclin
Family: Transporter
Novelty: 0.01011201
p_int: 0.999998674
p_ni: 0.000001325
p_wrong: 1e-9
Score: 0.941
Data Source: BioPlex,STRINGDB
TMEM8A
Tdark
Novelty: 0.15724279
p_int: 0.999944013
p_ni: 0.000055981
p_wrong: 6e-9
Score: 0.795
Data Source: BioPlex,STRINGDB
TMEM67
Tbio
Novelty: 0.02573267
p_int: 0.999464078
p_ni: 0.000535922
Data Source: BioPlex
TGFBR3
Tbio
Novelty: 0.0077307
p_int: 0.998818045
p_ni: 0.00118194
p_wrong: 1.5e-8
Data Source: BioPlex
TMEM59L
Tbio
Novelty: 0.22745646
p_int: 0.996610207
p_ni: 0.003260645
p_wrong: 0.000129148
Score: 0.183
Data Source: BioPlex,STRINGDB
ENTPD7
Tbio
Family: Enzyme
Novelty: 0.1810079
p_int: 0.991359368
p_ni: 0.008070139
p_wrong: 0.000570492
Data Source: BioPlex
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.977432654
p_ni: 0.02199594
p_wrong: 0.000571406
Data Source: BioPlex
BTN2A2
Tdark
Novelty: 0.46565474
p_int: 0.973600798
p_ni: 0.026399187
p_wrong: 1.5e-8
Data Source: BioPlex
RTN2
Tbio
Novelty: 0.05184418
p_int: 0.970198155
p_ni: 0.029801794
p_wrong: 5.1e-8
Data Source: BioPlex
ITGA7
Tbio
Novelty: 0.01243073
p_int: 0.926459351
p_ni: 0.073540649
Score: 0.155
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  11.05

PubMed score by year
PubTator Score  10.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer