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Tbio
VPS4A
Vacuolar protein sorting-associated protein 4A

Protein Summary
Description
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphory ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254950
  • ENSP00000254950
  • ENSG00000132612

Symbol
  • VPS4
  • SKD1
  • SKD2
  • VPS4
  • SKD1A
  • VPS4-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
molecular function
0.96
biological process
0.86
histone modification site profile
0.85
interacting protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.26   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.26   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (202)
Budding and maturation of HIV virion (R-HSA-162588)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
HIV Infection
HIV Life Cycle
Gene Ontology Terms (57)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (75)
1 – 10 of 75
ZFYVE19
Tbio
Novelty: 1.07142857
p_int: 0.999999991
p_wrong: 9e-9
Score: 0.761
Data Source: BioPlex,STRINGDB
VPS4B
Tbio
Novelty: 0.00983426
p_int: 0.999998837
p_ni: 0.000001163
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
VTA1
Tbio
Novelty: 0.02244131
p_int: 0.826061018
p_ni: 0.173897874
p_wrong: 0.000041108
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
ARL8B
Tbio
Family: Enzyme
Novelty: 0.08537963
p_int: 0.798036505
p_ni: 0.201778462
p_wrong: 0.000185033
Score: 0.238
Data Source: BioPlex,STRINGDB
CHMP6
Tbio
Novelty: 0.0478065
Score: 0.999
Data Source: STRINGDB
CHMP1A
Tbio
Novelty: 0.06086208
Score: 0.999
Data Source: STRINGDB
CHMP2A
Tbio
Novelty: 0.00337804
Score: 0.999
Data Source: STRINGDB
CHMP2B
Tbio
Novelty: 0.01676728
Score: 0.995
Data Source: STRINGDB
CHMP4B
Tbio
Novelty: 0.02197696
Score: 0.994
Data Source: STRINGDB
CHMP1B
Tbio
Novelty: 0.16112223
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.26

PubMed score by year
PubTator Score  128.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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