Tbio NDRG2 Protein NDRG2

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Protein Ndrg2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Protein Ndrg2

Protein Summary

Description

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q9UN36
• B3KUE3
• B4DE86
• B7WP11
• B7WPD5
• D3DS07
• D3DS10
• Q567T1
• Q68DW2
• Q86U08
• Q86U46
• Q96FD3
• Q96FT0
• Q96JU0
• Q96PN0
• Q9BQH5
• Q9ULH2

Gene Name

• NDRG2

Ensembl ID

• ENST00000298684
• ENSP00000298684
• ENSG00000165795
• ENST00000298687
• ENSP00000298687
• ENST00000350792
• ENSP00000344620
• ENST00000360463
• ENSP00000353649
• ENST00000397844
• ENSP00000380943
• ENST00000397847
• ENSP00000380945
• ENST00000397851
• ENSP00000380949
• ENST00000397853
• ENSP00000380951
• ENST00000397858
• ENSP00000380956
• ENST00000403829
• ENSP00000385889
• ENST00000553503
• ENSP00000452306
• ENST00000554143
• ENSP00000452006
• ENST00000555158
• ENSP00000452038
• ENST00000556147
• ENSP00000451712

Symbol

• KIAA1248
• SYLD
• SYLD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
disease perturbation	0.98
PubMedID	0.9
transcription factor perturbation	0.88
kinase	0.8

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.44   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 358   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.44   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

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1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2	2	3		86.6
hematocrit	EFO_0004348	3	1	3		77.1
testosterone measurement	EFO_0004908	2	1	2		76.3
red blood cell density measurement	EFO_0007978	1	1	1		69.4
platelet crit	EFO_0007985	1	1	1		54.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	3		86.6
hematocrit	EFO_0004348	3		77.1
testosterone measurement	EFO_0004908	2		76.3
red blood cell density measurement	EFO_0007978	1		69.4
platelet crit	EFO_0007985	1		54.4

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NDRG family member 2	VGNC:3379	100499579
Macaque	NDRG family member 2		706990
Mouse	N-myc downstream regulated gene 2	MGI:1352498	29811
Rat	NDRG family member 2	RGD:621874	171114
Dog	NDRG family member 2	VGNC:43679	609390

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NDRG family member 2
Macaque	NDRG family member 2
Mouse	N-myc downstream regulated gene 2
Rat	NDRG family member 2
Dog	NDRG family member 2

Protein Structure (3 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UN36-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (1)

PathwayCommons (1)

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1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	Validated targets of C-MYC transcriptional repression	63 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
Validated targets of C-MYC transcriptional repression	63 targets	PathwayCommons: pid

Gene Ontology Terms (16)

Components (7)

Processes (9)

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1 – 7 of 7

GO Term	Evidence	Assigned by
Golgi apparatus	Inferred from Direct Assay (IDA)	LIFEdb
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
cytoplasm	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytosol	Non-traceable Author Statement (NAS)	UniProtKB
growth cone	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
nucleus	Inferred from Electronic Annotation (IEA)	Ensembl
perinuclear region of cytoplasm	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (31)

Explore Interacting Targets

1 – 10 of 31

• See Interactions on String-DB

CDK15

Tchem

Family:  Kinase

Novelty:  0.3870338

p_int:  0.999767026

p_ni:  0.000232968

p_wrong:  6e-9

Score:  0.186

Data Source:  BioPlex,STRINGDB

DDX19B

Tbio

Family:  Enzyme

Novelty:  0.0504568

p_int:  0.99967292

p_ni:  0.000246361

p_wrong:  0.000080719

Data Source:  BioPlex

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.999411229

p_ni:  0.000127247

p_wrong:  0.000461524

Data Source:  BioPlex

NDRG1

Tbio

Novelty:  0.00352631

p_int:  0.910868455

p_ni:  0.004455789

p_wrong:  0.084675755

Score:  0.874

Data Source:  BioPlex,STRINGDB

HSPA8

Tchem

Novelty:  0.00081014

p_int:  0.835563035

p_ni:  0.164436965

Score:  0.179

Data Source:  BioPlex,STRINGDB

STK38L

Tchem

Family:  Kinase

Novelty:  0.05193219

Score:  0.907

Data Source:  STRINGDB

MYCN

Tbio

Family:  TF

Novelty:  0.00038165

Score:  0.731

Data Source:  STRINGDB

BCL7B

Tbio

Novelty:  0.11909054

Score:  0.664

Data Source:  STRINGDB

SGK1

Tchem

Family:  Kinase

Novelty:  0.00155681

Score:  0.639

Data Source:  STRINGDB

TP53

Tchem

Family:  TF

Novelty:  0.00001907

Score:  0.601

Data Source:  STRINGDB

Publication Statistics

PubMed Score  153.44

PubMed score by year

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PubTator Score  117.35

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell projection
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Neurogenesis
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
amino acid measurement
blood metabolite measurement
eosinophil cationic protein measurement
hematocrit
hemoglobin measurement
platelet crit
protein measurement
red blood cell density measurement
testosterone measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging
neoplasm