Protein Summary
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
- ENST00000298684
- ENSP00000298684
- ENSG00000165795
- ENST00000298687
- ENSP00000298687
- ENST00000350792
- ENSP00000344620
- ENST00000360463
- ENSP00000353649
- ENST00000397844
- ENSP00000380943
- ENST00000397847
- ENSP00000380945
- ENST00000397851
- ENSP00000380949
- ENST00000397853
- ENSP00000380951
- ENST00000397858
- ENSP00000380956
- ENST00000403829
- ENSP00000385889
- ENST00000553503
- ENSP00000452306
- ENST00000554143
- ENSP00000452006
- ENST00000555158
- ENSP00000452038
- ENST00000556147
- ENSP00000451712
- KIAA1248
- SYLD
- SYLD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 0.99 | ||
disease perturbation | 0.98 | ||
PubMedID | 0.9 | ||
transcription factor perturbation | 0.88 | ||
kinase | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.44 (req: < 5)
Gene RIFs: 109 (req: <= 3)
Antibodies: 358 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.44 (req: >= 5)
Gene RIFs: 109 (req: > 3)
Antibodies: 358 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (31)
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.999767026
p_ni: 0.000232968
p_wrong: 6e-9
Score: 0.186
Data Source: BioPlex,STRINGDB
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.99967292
p_ni: 0.000246361
p_wrong: 0.000080719
Data Source: BioPlex
KLHL11
Novelty: 0.1537041
p_int: 0.999411229
p_ni: 0.000127247
p_wrong: 0.000461524
Data Source: BioPlex
NDRG1
Novelty: 0.00352631
p_int: 0.910868455
p_ni: 0.004455789
p_wrong: 0.084675755
Score: 0.874
Data Source: BioPlex,STRINGDB
HSPA8
Novelty: 0.00081014
p_int: 0.835563035
p_ni: 0.164436965
Score: 0.179
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: pid | Validated targets of C-MYC transcriptional repression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Validated targets of C-MYC transcriptional repression | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Components (7)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | LIFEdb | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 2 | 2 | 3 | 86.6 | |||||
hematocrit | 3 | 1 | 3 | 77.1 | |||||
testosterone measurement | 2 | 1 | 2 | 76.3 | |||||
red blood cell density measurement | 1 | 1 | 1 | 69.4 | |||||
platelet crit | 1 | 1 | 1 | 54.4 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 86.6 | |||||
hematocrit | 3 | 77.1 | |||||
testosterone measurement | 2 | 76.3 | |||||
red blood cell density measurement | 1 | 69.4 | |||||
platelet crit | 1 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NDRG family member 2 | VGNC:3379 | 100499579 | |||||
Macaque | NDRG family member 2 | 706990 | ||||||
Mouse | MGI:1352498 | 29811 | ||||||
Rat | RGD:621874 | 171114 | ||||||
Dog | NDRG family member 2 | VGNC:43679 | 609390 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NDRG family member 2 | |||||
Macaque | NDRG family member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NDRG family member 2 | |||||
Publication Statistics
PubMed Score 153.44
PubMed score by year
PubTator Score 117.35
PubTator score by year
Related Publications
Text Mined References (133)
GeneRif Annotations (109)
Items per page:
0 of 0
PMID | Year | Title |
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