Tbio DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Protein Summary

Description

May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

Uniprot Accession IDs

• Q9UN19
• Q8TCK5
• Q9UHF2
• hDAPP1

Gene Name

• DAPP1

Ensembl ID

• ENST00000512369
• ENSP00000423602
• ENSG00000070190

Symbol

• BAM32
• BAM32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
small molecule perturbation	0.87
transcription factor perturbation	0.84
gene perturbation	0.8
PubMedID	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 382   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0