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Tbio
DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Protein Summary
Description
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512369
  • ENSP00000423602
  • ENSG00000070190

Symbol
  • BAM32
  • BAM32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
small molecule perturbation
0.87
transcription factor perturbation
0.84
gene perturbation
0.8
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Immune System
Reactome
Signaling by the B Cell Receptor (BCR)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Immune System
Signaling by the B Cell Receptor (BCR)
Protein-Protein Interactions (80)
1 – 10 of 80
SERPINF2
Tbio
Novelty: 0.00058646
p_int: 0.999983638
p_ni: 0.000016354
p_wrong: 8e-9
Data Source: BioPlex
GAK
Tchem
Family: Kinase
Novelty: 0.01252746
p_int: 0.999636866
p_ni: 0.000363133
p_wrong: 2e-9
Data Source: BioPlex
DCAF10
Tdark
Novelty: 10
p_int: 0.95907908
p_ni: 0.04092092
Data Source: BioPlex
RELA
Tchem
Family: TF
Novelty: 0.00091233
p_int: 0.905464869
p_ni: 0.089771172
p_wrong: 0.004763959
Data Source: BioPlex
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00086268
p_int: 0.886686093
p_ni: 0.113252584
p_wrong: 0.000061323
Data Source: BioPlex
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00370802
Score: 0.981
Data Source: Reactome,STRINGDB
BTK
Tclin
Family: Kinase
Novelty: 0.000673
Score: 0.977
Data Source: STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00040453
Score: 0.967
Data Source: STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00137519
Score: 0.964
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00009742
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.74

PubMed score by year
PubTator Score  15.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer