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Tbio
DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Protein Summary
Description
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512369
  • ENSP00000423602
  • ENSG00000070190

Symbol
  • BAM32
  • BAM32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
small molecule perturbation
0.87
transcription factor perturbation
0.84
gene perturbation
0.8
PubMedID
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
SERPINF2
Tbio
Novelty:  0.00054719
p_int:  0.999983638
p_ni:  0.000016354
p_wrong:  8e-9
Data Source:  BioPlex
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
p_int:  0.999636866
p_ni:  0.000363133
p_wrong:  2e-9
Data Source:  BioPlex
DCAF10
Tdark
Novelty:  2.6713128
p_int:  0.95907908
p_ni:  0.04092092
Data Source:  BioPlex
RELA
Tchem
Family:  TF
Novelty:  0.0007137
p_int:  0.905464869
p_ni:  0.089771172
p_wrong:  0.004763959
Data Source:  BioPlex
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
p_int:  0.886686093
p_ni:  0.113252584
p_wrong:  0.000061323
Data Source:  BioPlex
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.981
Data Source:  Reactome,STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
Score:  0.977
Data Source:  STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.967
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.964
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.953
Data Source:  STRINGDB
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Immune System
Reactome
Signaling by the B Cell Receptor (BCR)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Immune System
Signaling by the B Cell Receptor (BCR)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
2
1
0
9
75.6
mean corpuscular volume
1
1
1
67.1
red blood cell distribution width
2
1
2
55.2
mean reticulocyte volume
1
1
1
35
platelet count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
0
9
75.6
mean corpuscular volume
1
67.1
red blood cell distribution width
2
55.2
mean reticulocyte volume
1
35
platelet count
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
VGNC:10853
461398
Macaque
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
709038
Mouse
MGI:1347063
26377
Rat
RGD:1310189
362046
Dog
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
VGNC:39773
478491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Macaque
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Mouse
Rat
Dog
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Publication Statistics
PubMed Score 27.10
PubMed score by year
PubTator Score 15.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title