Protein Summary
May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins. This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
- ENST00000610513
- ENSP00000478707
- ENSG00000274047
- ENST00000612223
- ENSP00000483453
- ENSG00000275066
- ENST00000613407
- ENSP00000483152
- ENST00000614941
- ENSP00000481151
- ENST00000616179
- ENSP00000482962
- ENST00000618176
- ENSP00000482597
- ENST00000618402
- ENSP00000480288
- ENST00000619541
- ENSP00000477885
- ENST00000621136
- ENSP00000484529
- ENST00000622045
- ENSP00000483063
- ENST00000632841
- ENSP00000487672
- ENST00000633429
- ENSP00000488473
- AP1GBP1
- SYNG
- SYNG
- AP1GBP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.92 | ||
transcription factor binding site profile | 0.79 | ||
transcription factor | 0.78 | ||
cellular component | 0.75 | ||
histone modification site profile | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.05 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 30 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.05 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 30 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0