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Tdark
SYNRG
Synergin gamma

Protein Summary
Description
May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins. This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610513
  • ENSP00000478707
  • ENSG00000274047
  • ENST00000612223
  • ENSP00000483453
  • ENSG00000275066
  • ENST00000613407
  • ENSP00000483152
  • ENST00000614941
  • ENSP00000481151
  • ENST00000616179
  • ENSP00000482962
  • ENST00000618176
  • ENSP00000482597
  • ENST00000618402
  • ENSP00000480288
  • ENST00000619541
  • ENSP00000477885
  • ENST00000621136
  • ENSP00000484529
  • ENST00000622045
  • ENSP00000483063
  • ENST00000632841
  • ENSP00000487672
  • ENST00000633429
  • ENSP00000488473

Symbol
  • AP1GBP1
  • SYNG
  • SYNG
  • AP1GBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor binding site profile
0.79
transcription factor
0.78
cellular component
0.75
histone modification site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
65.5
cognitive function measurement
1
1
1
65.5
mathematical ability
1
1
1
63.6
mathematical ability
1
1
1
63.6
lymphocyte count
1
1
1
43
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
65.5
cognitive function measurement
1
65.5
mathematical ability
1
63.6
mathematical ability
1
63.6
lymphocyte count
1
43
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synergin gamma
717750
Mouse
MGI:1354742
217030
Dog
synergin gamma
VGNC:47038
480597
Horse
synergin gamma
VGNC:23811
100071490
Cow
synergin gamma
VGNC:35533
533098
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synergin gamma
Mouse
Dog
synergin gamma
Horse
synergin gamma
Cow
synergin gamma
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UMZ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (150)
1 – 10 of 150
AP1S2
Tbio
Novelty: 0.01413503
p_int: 1
Score: 0.913
Data Source: BioPlex,STRINGDB
AP1S3
Tbio
Novelty: 0.14425094
p_int: 0.999999967
p_ni: 3.3e-8
Data Source: BioPlex
MLF1
Tbio
Novelty: 0.0239522
p_int: 0.999992222
p_ni: 0.000007776
p_wrong: 2e-9
Data Source: BioPlex
AP1G2
Tbio
Novelty: 0.17203425
p_int: 0.999969914
p_ni: 0.000030078
p_wrong: 8e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999901177
p_ni: 0.000098797
p_wrong: 2.6e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.999880161
p_ni: 0.000119315
p_wrong: 5.24e-7
Score: 0.179
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.899690997
p_ni: 0.093883596
p_wrong: 0.006425407
Score: 0.175
Data Source: BioPlex,STRINGDB
AP1G1
Tbio
Novelty: 0.03754132
Score: 0.91
Data Source: STRINGDB
AFTPH
Tbio
Novelty: 0.21887849
Score: 0.87
Data Source: STRINGDB
CLTC
Tbio
Novelty: 0.00256674
Score: 0.866
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.19

PubMed score by year
PubTator Score  4.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer