Protein Summary
The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
- ENST00000451315
- ENSP00000405674
- ENSG00000225921
- C6orf90
- NOP27
- PQBP3
- RARG-1
- C6orf90
- dJ223E5.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
kinase perturbation | 0.96 | ||
histone modification site profile | 0.91 | ||
transcription factor binding site profile | 0.82 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.58 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 25 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.58 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 25 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0