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Tbio
GUCA1B
Guanylyl cyclase-activating protein 2

Protein Summary
Description
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230361
  • ENSP00000230361
  • ENSG00000112599

Symbol
  • GCAP2
  • RP48
  • GCAP2
  • GUCA2
  • GCAP 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
biological process
0.73
protein domain
0.73
cellular component
0.55
cell line
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
1
3
83.2
eosinophil percentage of leukocytes
2
1
2
81.5
monocyte percentage of leukocytes
1
1
1
48.5
sum of eosinophil and basophil counts
1
1
1
33.1
eosinophil percentage of granulocytes
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
83.2
eosinophil percentage of leukocytes
2
81.5
monocyte percentage of leukocytes
1
48.5
sum of eosinophil and basophil counts
1
33.1
eosinophil percentage of granulocytes
1
30.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 1B
VGNC:2854
472007
Macaque
guanylate cyclase activator 1B
695658
Mouse
MGI:1194489
107477
Rat
RGD:1308191
316218
Dog
guanylate cyclase activator 1B
VGNC:41562
481801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 1B
Macaque
guanylate cyclase activator 1B
Mouse
Rat
Dog
guanylate cyclase activator 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UMX6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (114)
1 – 10 of 114
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.992
Data Source:  STRINGDB
GUCY2F
Tbio
Family:  Kinase
Novelty:  0.03634576
Score:  0.986
Data Source:  STRINGDB
CNGA1
Tchem
Family:  IC
Novelty:  0.00848214
Score:  0.957
Data Source:  STRINGDB
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.948
Data Source:  STRINGDB
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.92
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.91
Data Source:  STRINGDB
GUCY2C
Tclin
Family:  Kinase
Novelty:  0.00209733
Score:  0.77
Data Source:  STRINGDB
GRK1
Tchem
Family:  Kinase
Novelty:  0.00598725
Score:  0.731
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.723
Data Source:  STRINGDB
GUCA2B
Tbio
Family:  Enzyme
Novelty:  0.02002363
Score:  0.717
Data Source:  STRINGDB
Publication Statistics
PubMed Score  46.44

PubMed score by year
PubTator Score  42.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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