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Tbio
SUFU
Suppressor of fused homolog

Protein Summary
Description
Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:27234298, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369899
  • ENSP00000358915
  • ENSG00000107882
  • ENST00000369902
  • ENSP00000358918
  • ENST00000423559
  • ENSP00000411597

Symbol
  • SUFUH
  • JBTS32
  • SUFUXL
  • PRO1280
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
biological process
0.94
transcription factor
0.86
phenotype
0.75
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.01   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.01   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
4
11
13
90.4
3
3
0
1
85.6
6
5
1
1.1
81.7
4
3
2
1
78.6
neutrophil count
2
2
2
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
13
90.4
0
1
85.6
1
1.1
81.7
2
1
78.6
neutrophil count
2
77.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUFU negative regulator of hedgehog signaling
VGNC:5794
450699
Macaque
SUFU negative regulator of hedgehog signaling
713576
Mouse
MGI:1345643
24069
Rat
RGD:1559462
361769
Dog
SUFU negative regulator of hedgehog signaling
VGNC:46971
608531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUFU negative regulator of hedgehog signaling
Macaque
SUFU negative regulator of hedgehog signaling
Mouse
Rat
Dog
SUFU negative regulator of hedgehog signaling
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UMX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Degradation of GLI1 by the proteasome (R-HSA-5610780)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of GLI1 by the proteasome
Reactome
Degradation of GLI2 by the proteasome
Reactome
GLI3 is processed to GLI3R by the proteasome
Reactome
Hedgehog 'off' state
Reactome
Hedgehog 'on' state
Name
Explore in Pharos
Explore in Source
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'off' state
Hedgehog 'on' state
Protein-Protein Interactions (181)
1 – 10 of 181
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.999999616
p_ni:  3.83e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999997786
p_ni:  0.000002214
Data Source:  BioPlex
GRP
Tbio
Novelty:  0.00034247
p_int:  0.999997631
p_ni:  0.000002369
Data Source:  BioPlex
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
p_int:  0.999994341
p_ni:  0.000005659
Score:  0.177
Data Source:  BioPlex,STRINGDB
NXPH3
Tdark
Novelty:  0.405045
p_int:  0.999993637
p_ni:  0.000006363
Score:  0.163
Data Source:  BioPlex,STRINGDB
ZNF747
Tdark
Novelty:  9
p_int:  0.999993551
p_ni:  0.000006449
Score:  0.398
Data Source:  BioPlex,STRINGDB
CDC25C
Tchem
Family:  Enzyme
Novelty:  0.00227769
p_int:  0.999993159
p_ni:  0.000006841
Score:  0.269
Data Source:  BioPlex,STRINGDB
ZNF213
Tbio
Family:  TF
Novelty:  0.24190639
p_int:  0.99998709
p_ni:  0.000012902
p_wrong:  8e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
p_int:  0.999984806
p_ni:  0.000015194
Data Source:  BioPlex
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.999984402
p_ni:  0.000015598
Score:  0.227
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  226.01

PubMed score by year
PubTator Score  106.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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