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Tbio
UBQLN1
Ubiquilin-1

Protein Summary
Description
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257468
  • ENSP00000257468
  • ENSG00000135018
  • ENST00000376395
  • ENSP00000365576

Symbol
  • DA41
  • PLIC1
  • DA41
  • DSK2
  • UBQN
  • XDRP1
  • PLIC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
protein domain
0.97
transcription factor binding site profile
0.86
interacting protein
0.82
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.44   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.44   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (357)
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.999936835
p_ni:  0.000063165
Data Source:  BioPlex
KDELR1
Tbio
Novelty:  0.0036468
p_int:  0.821175619
p_ni:  0.178824381
Score:  0.426
Data Source:  BioPlex,STRINGDB
UBE4B
Tbio
Novelty:  0.01396546
Score:  0.99
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.986
Data Source:  STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.967
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.96
Data Source:  STRINGDB
UBL7
Tdark
Novelty:  0.20935024
Score:  0.954
Data Source:  STRINGDB
UBE4A
Tbio
Novelty:  0.02576018
Score:  0.953
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.951
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
75.9
eosinophil count
1
1
1
67.9
eosinophil percentage of granulocytes
1
1
1
51.7
eosinophil percentage of leukocytes
1
1
1
51.4
daytime rest measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
75.9
eosinophil count
1
67.9
eosinophil percentage of granulocytes
1
51.7
eosinophil percentage of leukocytes
1
51.4
daytime rest measurement
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquilin 1
VGNC:4898
464550
Mouse
MGI:1860276
56085
Rat
RGD:620745
114590
Dog
ubiquilin 1
VGNC:48084
476312
Horse
ubiquilin 1
VGNC:24744
100052573
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquilin 1
Mouse
Rat
Dog
ubiquilin 1
Horse
ubiquilin 1
Publication Statistics
PubMed Score 118.44
PubMed score by year
PubTator Score 62.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title