Protein Summary
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of a ...more
- ENST00000257468
- ENSP00000257468
- ENSG00000135018
- ENST00000376395
- ENSP00000365576
- DA41
- PLIC1
- DA41
- DSK2
- UBQN
- XDRP1
- PLIC-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
protein domain | 0.97 | ||
transcription factor binding site profile | 0.86 | ||
interacting protein | 0.82 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.44 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 327 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.44 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 327 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (357)
KDELR1
Novelty: 0.0036468
p_int: 0.821175619
p_ni: 0.178824381
Score: 0.426
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (4)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (3)
Components (11)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 1 | 1 | 1 | 75.9 | |||||
eosinophil count | 1 | 1 | 1 | 67.9 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 51.7 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 51.4 | |||||
daytime rest measurement | 1 | 1 | 1 | 48.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 1 | 75.9 | |||||
eosinophil count | 1 | 67.9 | |||||
eosinophil percentage of granulocytes | 1 | 51.7 | |||||
eosinophil percentage of leukocytes | 1 | 51.4 | |||||
daytime rest measurement | 1 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquilin 1 | VGNC:4898 | 464550 | |||||
Mouse | MGI:1860276 | 56085 | ||||||
Rat | RGD:620745 | 114590 | ||||||
Dog | ubiquilin 1 | VGNC:48084 | 476312 | |||||
Horse | ubiquilin 1 | VGNC:24744 | 100052573 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquilin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquilin 1 | |||||
Horse | ubiquilin 1 | |||||
Publication Statistics
PubMed Score 118.44
PubMed score by year
PubTator Score 62.69
PubTator score by year
Related Publications
Text Mined References (89)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
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