Tbio NFU1 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

Protein Summary

Description

Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9UMS0
• B4DUL9
• Q53QE5
• Q6VNZ8
• Q7Z5B1
• Q7Z5B2
• Q9Y322

Gene Name

• NFU1

Ensembl ID

• ENST00000303698
• ENSP00000306965
• ENSG00000169599
• ENST00000394305
• ENSP00000377842
• ENST00000410022
• ENSP00000387219
• ENST00000462320
• ENSP00000418598

Symbol

• HIRIP5
• Nfu
• NifU
• HIRIP
• MMDS1
• NIFUC
• CGI-33
• HIRIP5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
histone modification site profile	0.82
virus perturbation	0.79
transcription factor binding site profile	0.73
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.79   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.79   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0