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Tbio
NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

Protein Summary
Description
Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303698
  • ENSP00000306965
  • ENSG00000169599
  • ENST00000394305
  • ENSP00000377842
  • ENST00000410022
  • ENSP00000387219
  • ENST00000462320
  • ENSP00000418598

Symbol
  • HIRIP5
  • Nfu
  • NifU
  • HIRIP
  • MMDS1
  • NIFUC
  • CGI-33
  • HIRIP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.82
virus perturbation
0.79
transcription factor binding site profile
0.73
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.78   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.78   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
Score:  0.962
Data Source:  STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
Score:  0.959
Data Source:  STRINGDB
ISCU
Tbio
Novelty:  0.0043097
Score:  0.957
Data Source:  STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
Score:  0.947
Data Source:  STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
Score:  0.944
Data Source:  STRINGDB
BOLA3
Tbio
Novelty:  0.06292339
Score:  0.933
Data Source:  STRINGDB
O95278
Tbio
Family:  Enzyme
Novelty:  0.00846992
Score:  0.905
Data Source:  STRINGDB
B3EWF7
Tbio
Novelty:  0.00846992
Score:  0.905
Data Source:  STRINGDB
LIAS
Tbio
Family:  Enzyme
Novelty:  0.01269062
Score:  0.903
Data Source:  STRINGDB
HSCB
Tbio
Novelty:  0.01330125
Score:  0.899
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
1
1
40.7
dentures
2
1
2
37.6
1
1
1
37.6
body mass index
1
1
1
31.4
mathematical ability
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
40.7
dentures
2
37.6
1
37.6
body mass index
1
31.4
mathematical ability
1
0.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFU1 iron-sulfur cluster scaffold
VGNC:309
470394
Mouse
MGI:1913290
56748
Rat
RGD:1307823
297416
Dog
NFU1 iron-sulfur cluster scaffold
VGNC:43787
612607
Horse
NFU1 iron-sulfur cluster scaffold
VGNC:20719
100050814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFU1 iron-sulfur cluster scaffold
Mouse
Rat
Dog
NFU1 iron-sulfur cluster scaffold
Horse
NFU1 iron-sulfur cluster scaffold
Publication Statistics
PubMed Score 82.78
PubMed score by year
PubTator Score 30.55
PubTator score by year
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Related Publications
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PMID
Year
Title