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Tbio
CLEC4A
C-type lectin domain family 4 member A

Protein Summary
Description
C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934). (Micro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229332
  • ENSP00000229332
  • ENSG00000111729
  • ENST00000345999
  • ENSP00000344646
  • ENST00000352620
  • ENSP00000247243
  • ENST00000360500
  • ENSP00000353690

Symbol
  • CLECSF6
  • DCIR
  • LLIR
  • DCIR
  • LLIR
  • CD367
  • DDB27
  • CLECSF6
  • HDCGC13P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
tissue sample
0.68
virus perturbation
0.68
cell type or tissue
0.62
cell line
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.19   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.19   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
velopharyngeal dysfunction
1
1
1
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
velopharyngeal dysfunction
1
49.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member A
VGNC:8375
104001126
Macaque
C-type lectin domain family 4 member A
716122
Mouse
MGI:1920399
73149
Mouse
MGI:3624119
474145
Rat
RGD:1359109
362430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member A
Macaque
C-type lectin domain family 4 member A
Mouse
Mouse
Rat
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UMR7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Immune System
Innate Immune System
Protein-Protein Interactions (102)
1 – 10 of 102
JAM3
Tbio
Novelty: 0.01028735
p_int: 0.999999997
p_ni: 3e-9
Data Source: BioPlex
ROBO1
Tbio
Novelty: 0.00494884
p_int: 0.999999856
p_ni: 1.42e-7
p_wrong: 1e-9
Data Source: BioPlex
ROR2
Tbio
Family: Kinase
Novelty: 0.01698587
p_int: 0.999999748
p_ni: 2.51e-7
p_wrong: 1e-9
Data Source: BioPlex
ALCAM
Tbio
Novelty: 0.00244371
p_int: 0.999998893
p_ni: 0.000001107
Data Source: BioPlex
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
p_int: 0.999998184
p_ni: 0.000001816
Data Source: BioPlex
IGDCC3
Tdark
Novelty: 0.01192143
p_int: 0.999997643
p_ni: 1.4e-8
p_wrong: 0.000002344
Data Source: BioPlex
FGFRL1
Tbio
Novelty: 0.02178846
p_int: 0.999997232
p_ni: 0.000002694
p_wrong: 7.3e-8
Data Source: BioPlex
ROR1
Tbio
Family: Kinase
Novelty: 0.03038955
p_int: 0.999992905
p_ni: 0.00000698
p_wrong: 1.14e-7
Data Source: BioPlex
FGFR3
Tclin
Family: Kinase
Novelty: 0.00071612
p_int: 0.999986226
p_ni: 0.000010352
p_wrong: 0.000003422
Data Source: BioPlex
IGSF8
Tbio
Novelty: 0.03016623
p_int: 0.999968472
p_ni: 0.000031528
Data Source: BioPlex
Publication Statistics
PubMed Score  63.19

PubMed score by year
PubTator Score  38.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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