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Tbio
PPT2
Lysosomal thioesterase PPT2

Protein Summary
Description
Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324816
  • ENSP00000320528
  • ENSG00000221988
  • ENST00000361568
  • ENSP00000354608
  • ENST00000375137
  • ENSP00000364279
  • ENST00000375143
  • ENSP00000364285
  • ENST00000383301
  • ENSP00000372789
  • ENSG00000206329
  • ENST00000395523
  • ENSP00000378894
  • ENST00000412651
  • ENSP00000416505
  • ENSG00000236649
  • ENST00000414356
  • ENSP00000398462
  • ENSG00000168452
  • ENST00000415972
  • ENSP00000408333
  • ENSG00000228116
  • ENST00000423347
  • ENSP00000406219
  • ENSG00000231618
  • ENST00000433748
  • ENSP00000410001
  • ENSG00000206256
  • ENST00000476214
  • ENSP00000432308
  • ENST00000480383
  • ENSP00000432502
  • ENST00000483565
  • ENSP00000431928
  • ENST00000488579
  • ENSP00000434992
  • ENST00000490624
  • ENSP00000433323
  • ENST00000493809
  • ENSP00000436963
  • ENSG00000227600
  • ENST00000496937
  • ENSP00000432964
  • ENST00000527704
  • ENSP00000433061

Symbol
  • G14
  • PPT-2
  • C6orf8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.68
phenotype
0.66
cell line
0.61
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0