PPT2
Lysosomal thioesterase PPT2
Protein Summary
Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]
- ENST00000324816
- ENSP00000320528
- ENSG00000221988
- ENST00000361568
- ENSP00000354608
- ENST00000375137
- ENSP00000364279
- ENST00000375143
- ENSP00000364285
- ENST00000383301
- ENSP00000372789
- ENSG00000206329
- ENST00000395523
- ENSP00000378894
- ENST00000412651
- ENSP00000416505
- ENSG00000236649
- ENST00000414356
- ENSP00000398462
- ENSG00000168452
- ENST00000415972
- ENSP00000408333
- ENSG00000228116
- ENST00000423347
- ENSP00000406219
- ENSG00000231618
- ENST00000433748
- ENSP00000410001
- ENSG00000206256
- ENST00000476214
- ENSP00000432308
- ENST00000480383
- ENSP00000432502
- ENST00000483565
- ENSP00000431928
- ENST00000488579
- ENSP00000434992
- ENST00000490624
- ENSP00000433323
- ENST00000493809
- ENSP00000436963
- ENSG00000227600
- ENST00000496937
- ENSP00000432964
- ENST00000527704
- ENSP00000433061
- G14
- PPT-2
- C6orf8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
virus perturbation | 0.68 | ||
phenotype | 0.66 | ||
cell line | 0.61 | ||
cellular component | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 207.56 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 117 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 207.56 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 117 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0