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Tbio
TBX20
T-box transcription factor TBX20

Protein Summary
Description
Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408931
  • ENSP00000386170
  • ENSG00000164532

Symbol
  • ASD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.9
PubMedID
0.61
histone modification site profile
0.6
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.14   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.14   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
45.7
birth weight
3
2
3
31.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
45.7
birth weight
3
31.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 20
VGNC:14099
467053
Macaque
T-box 20
707576
Mouse
MGI:1888496
57246
Rat
RGD:1309396
315497
Dog
T-box 20
VGNC:47172
482396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 20
Macaque
T-box 20
Mouse
Rat
Dog
T-box 20
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UMR3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Heart Development
WikiPathways
Heart Development
WikiPathways
Heart Development
WikiPathways
Heart Development
WikiPathways
Heart Development
Name
Explore in Pharos
Explore in Source
Heart Development
Heart Development
Heart Development
Heart Development
Heart Development
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (68)
1 – 10 of 68
SLC25A21
Tbio
Family:  Transporter
Novelty:  0.15355545
p_int:  0.999989585
p_ni:  0.000010384
p_wrong:  3.1e-8
Score:  0.859
Data Source:  BioPlex,STRINGDB
BLVRA
Tbio
Family:  Enzyme
Novelty:  0.00526407
p_int:  0.999897779
p_ni:  0.00010193
p_wrong:  2.91e-7
Score:  0.737
Data Source:  BioPlex,STRINGDB
PHF13
Tbio
Family:  Epigenetic
Novelty:  0.02577645
p_int:  0.999845766
p_ni:  0.000154234
Score:  0.86
Data Source:  BioPlex,STRINGDB
TLE4
Tbio
Novelty:  0.02094922
p_int:  0.999673718
p_ni:  0.000326282
Score:  0.514
Data Source:  BioPlex,STRINGDB
TBX18
Tbio
Family:  TF
Novelty:  0.01287164
p_int:  0.999264334
p_ni:  9.34e-7
p_wrong:  0.000734732
Data Source:  BioPlex
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.993659315
p_ni:  0.006340685
Score:  0.493
Data Source:  BioPlex,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.977071435
p_ni:  0.022928565
Score:  0.505
Data Source:  BioPlex,STRINGDB
DNASE1L2
Tbio
Family:  Enzyme
Novelty:  0.0152658
p_int:  0.917520436
p_ni:  0.082456498
p_wrong:  0.000023065
Score:  0.859
Data Source:  BioPlex,STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.92
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.911
Data Source:  STRINGDB
Publication Statistics
PubMed Score  89.14

PubMed score by year
PubTator Score  44.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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