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Tbio
DDX19B
ATP-dependent RNA helicase DDX19B

Protein Summary
Description
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288071
  • ENSP00000288071
  • ENSG00000157349
  • ENST00000355992
  • ENSP00000348271
  • ENST00000393657
  • ENSP00000377267
  • ENST00000451014
  • ENSP00000392639
  • ENST00000563392
  • ENSP00000456574
  • ENST00000568625
  • ENSP00000456757

Symbol
  • DBP5
  • DDX19
  • TDBP
  • DBP5
  • RNAh
  • DDX19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.94
kinase perturbation
0.84
interacting protein
0.82
co-expressed gene
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.25   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.25   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
DDX19A
Tdark
Family:  Enzyme
Novelty:  0.54074082
p_int:  0.999999996
p_ni:  4e-9
Score:  0.256
Data Source:  BioPlex,STRINGDB
FCGBP
Tbio
Novelty:  0.02772194
p_int:  0.999996528
p_ni:  0.000003447
p_wrong:  2.5e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.999996292
p_ni:  0.000003707
p_wrong:  1e-9
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.999991565
p_ni:  0.000008428
p_wrong:  8e-9
Data Source:  BioPlex
C3
Tclin
Novelty:  0.00019115
p_int:  0.999988431
p_ni:  0.000011568
Data Source:  BioPlex
PPL
Tbio
Novelty:  0.00684645
p_int:  0.999986178
p_ni:  0.000013822
Data Source:  BioPlex
MVP
Tbio
Novelty:  0.00380277
p_int:  0.99996631
p_ni:  0.000033623
p_wrong:  6.7e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
ANXA8
Tbio
Novelty:  0.00056216
p_int:  0.999957797
p_ni:  0.000042197
p_wrong:  6e-9
Data Source:  BioPlex
FGG
Tbio
Novelty:  0.00404457
p_int:  0.999953911
p_ni:  0.000046089
Data Source:  BioPlex
SULT2B1
Tbio
Family:  Enzyme
Novelty:  0.02652128
p_int:  0.99995012
p_ni:  0.000032238
p_wrong:  0.000017643
Score:  0.335
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
isoleucine measurement
2
2
1
9.5
89.8
leucine measurement
1
1
0
10
66.4
valine measurement
1
1
0
9.5
64.3
body height
1
1
1
63.1
amino acid measurement
1
1
1
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
isoleucine measurement
1
9.5
89.8
leucine measurement
0
10
66.4
valine measurement
0
9.5
64.3
body height
1
63.1
amino acid measurement
1
48
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 19B
VGNC:13694
454213
Macaque
DEAD-box helicase 19B [Source:HGNC Symbol;Acc:HGNC:2742]
Horse
ATP-dependent RNA helicase DDX19B
100054938
Pig
DEAD-box helicase 19B
100524746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 19B
Macaque
DEAD-box helicase 19B [Source:HGNC Symbol;Acc:HGNC:2742]
Horse
ATP-dependent RNA helicase DDX19B
Pig
DEAD-box helicase 19B
Publication Statistics
PubMed Score 23.25
PubMed score by year
PubTator Score 40.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title