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Tbio
BARX2
Homeobox protein BarH-like 2

Protein Summary
Description
Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity). This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281437
  • ENSP00000281437
  • ENSG00000043039
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
gene perturbation
0.82
protein domain
0.73
cell type or tissue
0.7
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.82   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.82   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
TBL1X
Tbio
Novelty:  0.00027212
Score:  0.736
Data Source:  STRINGDB
TBL1XR1
Tbio
Novelty:  0.00503043
Score:  0.723
Data Source:  STRINGDB
KLF7
Tbio
Family:  TF
Novelty:  0.01762331
Score:  0.584
Data Source:  STRINGDB
MYOD1
Tbio
Family:  TF
Novelty:  0.00053412
Score:  0.56
Data Source:  STRINGDB
NFIA
Tbio
Family:  TF
Novelty:  0.00754859
Score:  0.557
Data Source:  STRINGDB
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.544
Data Source:  STRINGDB
CDH6
Tbio
Novelty:  0.01278517
Score:  0.541
Data Source:  STRINGDB
HS3ST4
Tbio
Family:  Enzyme
Novelty:  0.17854401
Score:  0.531
Data Source:  STRINGDB
HES6
Tbio
Family:  TF
Novelty:  0.01546524
Score:  0.522
Data Source:  STRINGDB
RPS26
Tbio
Novelty:  0.0183394
Score:  0.509
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
7.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BARX homeobox 2
VGNC:3203
466847
Mouse
MGI:109617
12023
Rat
RGD:1584840
679701
Dog
BARX homeobox 2
VGNC:38383
609212
Horse
BARX homeobox 2
VGNC:15768
100072628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BARX homeobox 2
Mouse
Rat
Dog
BARX homeobox 2
Horse
BARX homeobox 2
Publication Statistics
PubMed Score 27.82
PubMed score by year
PubTator Score 9.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title