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Tbio
ICAM5
Intercellular adhesion molecule 5

Protein Summary
Description
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221980
  • ENSP00000221980
  • ENSG00000105376

Symbol
  • TLCN
  • TLN
  • TLN
  • TLCN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
protein domain
0.92
transcription factor
0.74
transcription factor binding site profile
0.74
histone modification site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.23   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.23   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
2
3
0
13.8
97.6
IGF-1 measurement
1
4
4
96.7
reticulocyte count
7
7
13
95.2
6
5
0
1.2
92
myeloid white cell count
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
0
13.8
97.6
IGF-1 measurement
4
96.7
reticulocyte count
13
95.2
0
1.2
92
myeloid white cell count
2
91.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 5
VGNC:2349
455699
Mouse
MGI:109430
15898
Rat
RGD:1305039
313785
Dog
intercellular adhesion molecule 5
VGNC:41857
484958
Cow
intercellular adhesion molecule 5
VGNC:30025
505158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intercellular adhesion molecule 5
Mouse
Rat
Dog
intercellular adhesion molecule 5
Cow
intercellular adhesion molecule 5
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UMF0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Extracellular matrix organization
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (37)
1 – 10 of 37
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.993
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.951
Data Source:  STRINGDB
PSEN1
Tchem
Family:  Enzyme
Novelty:  0.00024189
Score:  0.789
Data Source:  STRINGDB
RHAG
Tbio
Novelty:  0.00094983
Score:  0.628
Data Source:  STRINGDB
TMED10
Tbio
Novelty:  0.02742083
Score:  0.62
Data Source:  STRINGDB
PSEN2
Tchem
Family:  Enzyme
Novelty:  0.00112188
Score:  0.555
Data Source:  STRINGDB
S1PR2
Tchem
Family:  GPCR
Novelty:  0.00372765
Score:  0.544
Data Source:  STRINGDB
C1QL4
Tdark
Novelty:  0.37071722
Score:  0.53
Data Source:  STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
Score:  0.525
Data Source:  STRINGDB
C1QL2
Tdark
Novelty:  0.18582872
Score:  0.523
Data Source:  STRINGDB
Publication Statistics
PubMed Score  83.23

PubMed score by year
PubTator Score  62.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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