Tbio COL17A1 Collagen alpha-1(XVII) chain

Protein Summary

Description

May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UMD9
• Q02802
• Q5JV36
• Q99018
• Q9NQK9
• Q9UC14

Gene Name

• COL17A1

Ensembl ID

• ENST00000353479
• ENSP00000340937
• ENSG00000065618
• ENST00000369733
• ENSP00000358748
• ENST00000648076
• ENSP00000497653

Symbol

• BP180
• BPAG2
• ERED
• BP180
• BPA-2
• BPAG2
• LAD-1
• BA16H23.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.69
cellular component	0.68
gene perturbation	0.58
cell type or tissue	0.53
disease	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.59   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.59   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0