You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
ALK
ALK tyrosine kinase receptor

Protein Summary
Description
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389048
  • ENSP00000373700
  • ENSG00000171094

Symbol
  • CD246
  • NBLST3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
molecular function
0.99
hub protein
0.95
biological term
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5031.25   (req: < 5)
Gene RIFs: 572   (req: <= 3)
Antibodies: 1078   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5031.25   (req: >= 5)
Gene RIFs: 572   (req: > 3)
Antibodies: 1078   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 775
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
79.2
self reported educational attainment
1
1
1
71.1
HIV-1 infection
1
1
1
62.3
viral load
1
1
1
62.3
response to carbamazepine
1
1
0
12.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
79.2
self reported educational attainment
1
71.1
HIV-1 infection
1
62.3
viral load
1
62.3
response to carbamazepine
0
12.1
31.4
Protein Data Bank (57)
1 – 5 of 57
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
PD-L1 expression and PD-1 checkpoint pathway in cancer
KEGG
Pathways in cancer
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Pathways in cancer
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (239)
1 – 10 of 239
EML4
Tbio
Novelty: 0.00217772
Score: 0.986
Data Source: STRINGDB
FRS3
Tbio
Novelty: 0.09479379
Score: 0.962
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.95
Data Source: STRINGDB
TNFRSF8
Tclin
Novelty: 0.00030231
Score: 0.933
Data Source: STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.905
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.903
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.891
Data Source: STRINGDB
NPM1
Tbio
Novelty: 0.0005485
Score: 0.886
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.874
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.863
Data Source: STRINGDB
Publication Statistics
PubMed Score  5031.25

PubMed score by year
PubTator Score  2596.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: