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Tclin
ALK
ALK tyrosine kinase receptor

Protein Summary
Description
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389048
  • ENSP00000373700
  • ENSG00000171094

Symbol
  • CD246
  • NBLST3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
molecular function
0.99
hub protein
0.95
biological term
0.8


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5294.2   (req: < 5)
Gene RIFs: 572   (req: <= 3)
Antibodies: 1078   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5294.2   (req: >= 5)
Gene RIFs: 572   (req: > 3)
Antibodies: 1078   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 905
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
69.3
smoking status measurement
2
1
2
49.5
self reported educational attainment
1
1
1
42.3
dentures
1
1
1
33.1
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
69.3
smoking status measurement
2
49.5
self reported educational attainment
1
42.3
dentures
1
33.1
1
33.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALK receptor tyrosine kinase
VGNC:10681
459127
Macaque
ALK receptor tyrosine kinase
704823
Mouse
MGI:103305
11682
Rat
RGD:628622
266802
Dog
ALK receptor tyrosine kinase
VGNC:37802
483021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALK receptor tyrosine kinase
Macaque
ALK receptor tyrosine kinase
Mouse
Rat
Dog
ALK receptor tyrosine kinase
Protein Structure (57 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UM73-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 57
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
PD-L1 expression and PD-1 checkpoint pathway in cancer
KEGG
Pathways in cancer
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Pathways in cancer
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (239)
1 – 10 of 239
EML4
Tbio
Novelty:  0.00217772
Score:  0.986
Data Source:  STRINGDB
FRS3
Tbio
Novelty:  0.09479379
Score:  0.962
Data Source:  STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.95
Data Source:  STRINGDB
TNFRSF8
Tclin
Novelty:  0.00030231
Score:  0.933
Data Source:  STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.905
Data Source:  STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.903
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.891
Data Source:  STRINGDB
NPM1
Tbio
Novelty:  0.0005485
Score:  0.886
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.874
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.863
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5294.20

PubMed score by year
PubTator Score  2596.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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