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Tbio
PLAGL1
Zinc finger protein PLAGL1

Protein Summary
Description
Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354765
  • ENSP00000346810
  • ENSG00000118495
  • ENST00000360537
  • ENSP00000353734
  • ENST00000367571
  • ENSP00000356543
  • ENST00000367572
  • ENSP00000356544
  • ENST00000416623
  • ENSP00000400060
  • ENST00000417959
  • ENSP00000395960
  • ENST00000437412
  • ENSP00000392418
  • ENST00000444202
  • ENSP00000400929
  • ENST00000625622
  • ENSP00000486355
  • ENST00000647880
  • ENSP00000496815
  • ENST00000649211
  • ENSP00000497492
  • ENST00000649307
  • ENSP00000496979
  • ENST00000650125
  • ENSP00000497363

Symbol
  • LOT1
  • ZAC
  • ZAC
  • LOT1
  • ZAC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.98
virus perturbation
0.92
gene perturbation
0.79
histone modification site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.11   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.11   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.97
Data Source:  STRINGDB
PEG3
Tbio
Family:  TF
Novelty:  0.00367006
Score:  0.714
Data Source:  STRINGDB
ADCYAP1
Tbio
Family:  Enzyme
Novelty:  0.00080219
Score:  0.713
Data Source:  STRINGDB
PEG10
Tbio
Novelty:  0.00478545
Score:  0.71
Data Source:  STRINGDB
SNRPN
Tbio
Novelty:  0.002157
Score:  0.692
Data Source:  STRINGDB
GRB10
Tbio
Novelty:  0.00762794
Score:  0.68
Data Source:  STRINGDB
NNAT
Tbio
Novelty:  0.01079637
Score:  0.675
Data Source:  STRINGDB
SGCE
Tbio
Novelty:  0.00449577
Score:  0.669
Data Source:  STRINGDB
MEST
Tbio
Family:  Enzyme
Novelty:  0.00226252
Score:  0.659
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.657
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (155)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Cycle Genes
Reactome
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Cycle Genes
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
3
89.9
testosterone measurement
2
2
2
72.8
viral load
1
1
1
68.6
monocyte count
2
1
2
49.2
neutrophil percentage of leukocytes
2
1
2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
89.9
testosterone measurement
2
72.8
viral load
1
68.6
monocyte count
2
49.2
neutrophil percentage of leukocytes
2
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PLAG1 like zinc finger 1
VGNC:7903
463042
Macaque
PLAG1 like zinc finger 1
699985
Mouse
MGI:1100874
22634
Rat
RGD:3014
25157
Dog
PLAG1 like zinc finger 1
VGNC:44639
484018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PLAG1 like zinc finger 1
Macaque
PLAG1 like zinc finger 1
Mouse
Rat
Dog
PLAG1 like zinc finger 1
Publication Statistics
PubMed Score 128.11
PubMed score by year
PubTator Score 152.82
PubTator score by year
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Related Publications
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PMID
Year
Title