Tbio MYO6 Unconventional myosin-VI

Protein Summary

Description

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity). This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9UM54
• A6H8V4
• E1P540
• Q5TEM5
• Q5TEM6
• Q5TEM7
• Q9BZZ7
• Q9UEG2

Gene Name

• MYO6

Ensembl ID

• ENST00000369977
• ENSP00000358994
• ENSG00000196586
• ENST00000369985
• ENSP00000359002
• ENST00000615563
• ENSP00000478013

Symbol

• KIAA0389
• DFNA22
• DFNB37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
molecular function	0.99
interacting protein	0.98
biological process	0.87
microRNA	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Unconventional Myosin-vi

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Unconventional Myosin-vi

Protein / Cell Junction Protein / Unconventional Myosin-vi

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Unconventional Myosin-vi

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.08   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.08   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0