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Tbio
MYO6
Unconventional myosin-VI

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity). This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369977
  • ENSP00000358994
  • ENSG00000196586
  • ENST00000369985
  • ENSP00000359002
  • ENST00000615563
  • ENSP00000478013

Symbol
  • KIAA0389
  • DFNA22
  • DFNB37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
interacting protein
0.98
biological process
0.87
microRNA
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.15   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.15   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (201)
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999960497
p_ni:  0.000039482
p_wrong:  2e-8
Score:  0.377
Data Source:  BioPlex,STRINGDB
FBXO34
Tdark
Novelty:  5.6683456
p_int:  0.997403298
p_ni:  0.002596702
Score:  0.826
Data Source:  BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty:  0.04851082
p_int:  0.996485085
p_ni:  0.003514915
Score:  0.348
Data Source:  BioPlex,STRINGDB
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.984657486
p_ni:  0.015340214
p_wrong:  0.0000023
Score:  0.179
Data Source:  BioPlex,STRINGDB
ARHGEF12
Tchem
Novelty:  0.01365866
p_int:  0.960926717
p_ni:  0.039072839
p_wrong:  4.44e-7
Score:  0.38
Data Source:  BioPlex,STRINGDB
FBXO30
Tdark
Novelty:  0.60394319
p_int:  0.959105354
p_ni:  0.040894646
Score:  0.71
Data Source:  BioPlex,STRINGDB
TMOD2
Tbio
Novelty:  0.10324176
p_int:  0.956786908
p_ni:  0.043213092
Score:  0.671
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.924462269
p_ni:  0.075537731
Score:  0.285
Data Source:  BioPlex,STRINGDB
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.829244532
p_ni:  0.170755468
Score:  0.392
Data Source:  BioPlex,STRINGDB
GSN
Tbio
Novelty:  0.00060852
p_int:  0.788685965
p_ni:  0.211314035
Score:  0.747
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Gap junction degradation (R-HSA-190873)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction degradation
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Gap junction degradation
Gap junction trafficking
Gap junction trafficking and regulation
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Membrane Trafficking
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
5
63.6
1
1
0
1.1
15.8
intelligence
1
1
0
5.5
15.8
BMI-adjusted waist circumference
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
63.6
0
1.1
15.8
intelligence
0
5.5
15.8
BMI-adjusted waist circumference
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin VI
VGNC:11129
462831
Macaque
myosin VI
716634
Mouse
MGI:104785
17920
Rat
RGD:1560646
315840
Dog
myosin VI
VGNC:43571
481884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin VI
Macaque
myosin VI
Mouse
Rat
Dog
myosin VI
Publication Statistics
PubMed Score 97.15
PubMed score by year
PubTator Score 197.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title