Tbio MYO6 Unconventional myosin-VI

Protein Summary

Description

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity). This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9UM54
• A6H8V4
• E1P540
• Q5TEM5
• Q5TEM6
• Q5TEM7
• Q9BZZ7
• Q9UEG2

Gene Name

• MYO6

Ensembl ID

• ENST00000369977
• ENSP00000358994
• ENSG00000196586
• ENST00000369985
• ENSP00000359002
• ENST00000615563
• ENSP00000478013

Symbol

• KIAA0389
• DFNA22
• DFNB37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
molecular function	0.99
interacting protein	0.98
biological process	0.87
microRNA	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Unconventional Myosin-vi

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Unconventional Myosin-vi

Protein / Cell Junction Protein / Unconventional Myosin-vi

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Unconventional Myosin-vi

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.15   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.15   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (201)

Explore Interacting Targets

1 – 10 of 201

• See Interactions on String-DB

POTEI

Tdark

Novelty:  0.41311202

p_int:  0.999960497

p_ni:  0.000039482

p_wrong:  2e-8

Score:  0.377

Data Source:  BioPlex,STRINGDB

FBXO34

Tdark

Novelty:  5.6683456

p_int:  0.997403298

p_ni:  0.002596702

Score:  0.826

Data Source:  BioPlex,STRINGDB

PPP1R9A

Tbio

Novelty:  0.04851082

p_int:  0.996485085

p_ni:  0.003514915

Score:  0.348

Data Source:  BioPlex,STRINGDB

CUEDC1

Tbio

Novelty:  0.14401061

p_int:  0.984657486

p_ni:  0.015340214

p_wrong:  0.0000023

Score:  0.179

Data Source:  BioPlex,STRINGDB

ARHGEF12

Tchem

Novelty:  0.01365866

p_int:  0.960926717

p_ni:  0.039072839

p_wrong:  4.44e-7

Score:  0.38

Data Source:  BioPlex,STRINGDB

FBXO30

Tdark

Novelty:  0.60394319

p_int:  0.959105354

p_ni:  0.040894646

Score:  0.71

Data Source:  BioPlex,STRINGDB

TMOD2

Tbio

Novelty:  0.10324176

p_int:  0.956786908

p_ni:  0.043213092

Score:  0.671

Data Source:  BioPlex,STRINGDB

ACTBL2

Tbio

Novelty:  0.18080702

p_int:  0.924462269

p_ni:  0.075537731

Score:  0.285

Data Source:  BioPlex,STRINGDB

MYL12B

Tbio

Novelty:  0.00999083

p_int:  0.829244532

p_ni:  0.170755468

Score:  0.392

Data Source:  BioPlex,STRINGDB

GSN

Tbio

Novelty:  0.00060852

p_int:  0.788685965

p_ni:  0.211314035

Score:  0.747

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (10)

PathwayCommons (3)

WikiPathways (2)

Gap junction degradation (R-HSA-190873)

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Find Similar Targets

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5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gap junction degradation	10 targets	R-HSA-190873
Reactome	Gap junction trafficking	28 targets	R-HSA-190828
Reactome	Gap junction trafficking and regulation	30 targets	R-HSA-157858
Reactome	Glutamate binding, activation of AMPA receptors and synaptic plasticity	31 targets	R-HSA-399721
Reactome	Membrane Trafficking	612 targets	R-HSA-199991

Name	Explore in Pharos	Explore in Source
Gap junction degradation	10 targets	R-HSA-190873
Gap junction trafficking	28 targets	R-HSA-190828
Gap junction trafficking and regulation	30 targets	R-HSA-157858
Glutamate binding, activation of AMPA receptors and synaptic plasticity	31 targets	R-HSA-399721
Membrane Trafficking	612 targets	R-HSA-199991

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (40)

Functions (8)

Components (24)

Processes (8)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ADP binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
calmodulin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
motor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
actin binding	Traceable Author Statement (TAS)	UniProtKB
minus-end directed microfilament motor activity	Non-traceable Author Statement (NAS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	2	5	5		63.6
prostate carcinoma	EFO_0001663	1	1	0	1.1	15.8
intelligence	EFO_0004337	1	1	0	5.5	15.8
BMI-adjusted waist circumference	EFO_0007789	1	1	1		5.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	5		63.6
prostate carcinoma	EFO_0001663	0	1.1	15.8
intelligence	EFO_0004337	0	5.5	15.8
BMI-adjusted waist circumference	EFO_0007789	1		5.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Actin-binding
Alternative splicing
ATP-binding
Calmodulin-binding
Cardiomyopathy
Cell membrane
Cell projection
Coated pit
Complete proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist circumference
intelligence
prostate carcinoma

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
muscle phenotype
nervous system phenotype
reproductive system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myosin VI	VGNC:11129	462831
Macaque	myosin VI		716634
Mouse	myosin VI	MGI:104785	17920
Rat	myosin VI	RGD:1560646	315840
Dog	myosin VI	VGNC:43571	481884

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myosin VI
Macaque	myosin VI
Mouse	myosin VI
Rat	myosin VI
Dog	myosin VI

Publication Statistics

PubMed Score 97.15

PubMed score by year

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PubTator Score 197.41

PubTator score by year

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Related Publications

Text Mined References (102)

GeneRif Annotations (66)

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PMID	Year	Title