NOTCH3
Neurogenic locus notch homolog protein 3
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
biological term | 0.98 | ||
disease perturbation | 0.93 | ||
cell type or tissue | 0.81 | ||
PubMedID | 0.8 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Defective LFNG causes SCDO3 | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Defective LFNG causes SCDO3 | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Gene expression (Transcription) | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 63.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 57.8 | |||||
reticulocyte measurement | 1 | 1 | 1 | 56.4 | |||||
platelet count | 1 | 1 | 1 | 52.7 | |||||
Anti-Toxoplasma gondii IgG measurement | 1 | 1 | 1 | 15.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 63.7 | |||||
mean reticulocyte volume | 1 | 57.8 | |||||
reticulocyte measurement | 1 | 56.4 | |||||
platelet count | 1 | 52.7 | |||||
Anti-Toxoplasma gondii IgG measurement | 1 | 15.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | notch 3 | VGNC:2302 | 455792 | |||||
Mouse | MGI:99460 | 18131 | ||||||
Rat | RGD:620761 | 56761 | ||||||
Dog | notch 3 | VGNC:43899 | 610439 | |||||
Horse | notch 3 | VGNC:20818 | 100146771 | |||||
PMID | Year | Title |
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