You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NOTCH3
Neurogenic locus notch homolog protein 3

Protein Summary
Description
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy wi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263388
  • ENSP00000263388
  • ENSG00000074181

Symbol
  • IMF2
  • LMNS
  • CASIL
  • CADASIL
  • CADASIL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological term
0.98
disease perturbation
0.93
cell type or tissue
0.81
PubMedID
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1113.95   (req: < 5)
Gene RIFs: 305   (req: <= 3)
Antibodies: 655   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1113.95   (req: >= 5)
Gene RIFs: 305   (req: > 3)
Antibodies: 655   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-Toxoplasma gondii IgG measurement
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-Toxoplasma gondii IgG measurement
1
11.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
notch 3
VGNC:2302
455792
Mouse
MGI:99460
18131
Rat
RGD:620761
56761
Dog
notch 3
VGNC:43899
610439
Horse
notch 3
VGNC:20818
100146771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
notch 3
Mouse
Rat
Dog
notch 3
Horse
notch 3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (47)
Defective LFNG causes SCDO3 (R-HSA-5083630)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective LFNG causes SCDO3
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Defective LFNG causes SCDO3
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Gene expression (Transcription)
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (208)
1 – 10 of 208
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.999999305
p_ni: 6.95e-7
p_wrong: 1e-9
Score: 0.375
Data Source: BioPlex,STRINGDB
ANKRD44
Tdark
Family: Enzyme
Novelty: 0.38360979
p_int: 0.999915535
p_ni: 0.000084458
p_wrong: 7e-9
Score: 0.347
Data Source: BioPlex,STRINGDB
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.0424259
p_int: 0.994802865
p_ni: 0.005197131
p_wrong: 4e-9
Score: 0.176
Data Source: BioPlex,STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
p_int: 0.994284286
p_ni: 0.005715431
p_wrong: 2.83e-7
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
DLK2
Tbio
Novelty: 0.06366405
p_int: 0.992306434
p_ni: 0.007692187
p_wrong: 0.000001379
Score: 0.189
Data Source: BioPlex,STRINGDB
ADAM33
Tchem
Family: Enzyme
Novelty: 0.00584097
p_int: 0.987737007
p_ni: 0.012262985
p_wrong: 8e-9
Score: 0.224
Data Source: BioPlex,STRINGDB
ADAM32
Tdark
Family: Enzyme
Novelty: 0.36071191
p_int: 0.982284194
p_ni: 0.017715798
p_wrong: 8e-9
Score: 0.174
Data Source: BioPlex,STRINGDB
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.982284194
p_ni: 0.017715798
p_wrong: 8e-9
Data Source: BioPlex
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.977606611
p_ni: 0.022305342
p_wrong: 0.000088047
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.968713905
p_ni: 0.031285885
p_wrong: 2.1e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  1113.95

PubMed score by year
PubTator Score  776.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: