Tbio EPDR1 Mammalian ependymin-related protein 1

Protein Summary

Description

The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9UM22
• A8K4C0
• C9JYS3
• Q06BL0
• Q99M77
• MERP-1

Gene Name

• EPDR1

Ensembl ID

• ENST00000199448
• ENSP00000199448
• ENSG00000086289
• ENST00000423717
• ENSP00000409211
• ENST00000425345
• ENSP00000413359

Symbol

• MERP1
• UCC1
• EPDR
• UCC1
• MERP1
• MERP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
interacting protein	0.73
microRNA	0.63
cellular component	0.54
small molecule perturbation	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.91   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.91   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0