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Tbio
MGAT4A
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Protein Summary
Description
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells. This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availab ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264968
  • ENSP00000264968
  • ENSG00000071073
  • ENST00000393487
  • ENSP00000377127
  • ENST00000409391
  • ENSP00000386841
  • ENST00000414521
  • ENSP00000404889

Symbol
  • GNT-IV
  • GnT-4a
  • GNT-IVA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.81
gene perturbation
0.72
transcription factor perturbation
0.68
cell type or tissue
0.65
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999995
p_ni:  5e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
MGAT5
Tbio
Family:  Enzyme
Novelty:  0.00707747
Score:  0.983
Data Source:  STRINGDB
MGAT3
Tchem
Family:  Enzyme
Novelty:  0.04261352
Score:  0.982
Data Source:  STRINGDB
MGAT2
Tchem
Family:  Enzyme
Novelty:  0.02440696
Score:  0.976
Data Source:  STRINGDB
MGAT5B
Tbio
Family:  Enzyme
Novelty:  0.07278117
Score:  0.974
Data Source:  STRINGDB
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
Score:  0.966
Data Source:  STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.907
Data Source:  STRINGDB
FUCA2
Tchem
Family:  Enzyme
Novelty:  0.02259158
Score:  0.905
Data Source:  STRINGDB
AFP
Tbio
Novelty:  0.00004755
Score:  0.904
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-Glycan antennae elongation
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-Glycan antennae elongation
N-glycan antennae elongation in the medial/trans-Golgi
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
progression free survival
1
1
0
2.1
21.5
metastatic colorectal cancer
1
1
0
2.1
21.5
response to CAPOX-B
1
1
0
2.1
21.5
response to cetuximab
1
1
0
2.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
progression free survival
0
2.1
21.5
metastatic colorectal cancer
0
2.1
21.5
response to CAPOX-B
0
2.1
21.5
response to cetuximab
0
2.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
459434
Macaque
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
708094
Mouse
MGI:2662992
269181
Rat
RGD:1305650
367252
Dog
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
VGNC:54527
474562
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
Macaque
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
Mouse
Rat
Dog
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
Publication Statistics
PubMed Score 21.25
PubMed score by year
PubTator Score 12.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title