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Tdark
HPCAL4
Hippocalcin-like protein 4

Protein Summary
Description
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372844
  • ENSP00000361935
  • ENSG00000116983
  • ENST00000617690
  • ENSP00000481834

Symbol
  • HLP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
protein domain
0.73
gene perturbation
0.69
histone modification site profile
0.65
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.999997724
p_ni:  6.89e-7
p_wrong:  0.000001587
Score:  0.165
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.999996622
p_ni:  0.000003354
p_wrong:  2.4e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999981112
p_ni:  0.000018877
p_wrong:  1.2e-8
Data Source:  BioPlex
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999832416
p_ni:  0.000006909
p_wrong:  0.000160676
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.99977273
p_ni:  0.00022339
p_wrong:  0.00000388
Data Source:  BioPlex
FAM131C
Tdark
Novelty:  5.67998554
Score:  0.751
Data Source:  STRINGDB
CALY
Tbio
Novelty:  0.05038488
Score:  0.678
Data Source:  STRINGDB
RNPEP
Tchem
Family:  Enzyme
Novelty:  0.00381273
Score:  0.653
Data Source:  STRINGDB
RSBN1
Tbio
Novelty:  0.1955858
Score:  0.611
Data Source:  STRINGDB
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
Score:  0.585
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
2
4
68.8
triglyceride measurement
1
1
1
32.9
apolipoprotein A 1 measurement
1
1
1
29
metabolic syndrome
1
1
1
21.4
appendicular lean mass
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
68.8
triglyceride measurement
1
32.9
apolipoprotein A 1 measurement
1
29
metabolic syndrome
1
21.4
appendicular lean mass
1
12.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hippocalcin like 4
VGNC:1265
748547
Mouse
MGI:2157521
170638
Rat
RGD:708491
50872
Dog
hippocalcin like 4
VGNC:41769
607789
Horse
hippocalcin like 4
VGNC:50703
100054144
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hippocalcin like 4
Mouse
Rat
Dog
hippocalcin like 4
Horse
hippocalcin like 4
Publication Statistics
PubMed Score 4.10
PubMed score by year
PubTator Score 2.54
PubTator score by year
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Related Publications
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PMID
Year
Title