You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ANAPC10
Anaphase-promoting complex subunit 10

Protein Classes
Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309439
  • ENSP00000310071
  • ENSG00000164162
  • ENST00000451299
  • ENSP00000403891
  • ENST00000507656
  • ENSP00000423995
  • ENST00000613466
  • ENSP00000478501

Symbol
  • APC10
  • DOC1
  • APC10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
virus perturbation
0.88
transcription factor binding site profile
0.85
kinase perturbation
0.84
histone modification site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.11   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.11   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
1
2
95.8
body height
4
3
4
92.8
appendicular lean mass
1
2
2
85.9
waist-hip ratio
1
1
1
76.7
hip circumference
1
1
2
59.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
95.8
body height
4
92.8
appendicular lean mass
2
85.9
waist-hip ratio
1
76.7
hip circumference
2
59.3
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (64)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (414)
1 – 10 of 414
ANAPC5
Tbio
Family: Enzyme
Novelty: 0.02102572
p_int: 0.996804064
p_ni: 0.003195936
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC16
Tdark
Family: Enzyme
Novelty: 0.06353035
p_int: 0.985346837
p_ni: 0.014653163
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC13
Tbio
Family: Enzyme
Novelty: 0.06125489
p_int: 0.985168546
p_ni: 0.014831439
p_wrong: 1.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.870525628
p_ni: 0.129077378
p_wrong: 0.000396994
Data Source: BioPlex
SMPD2
Tchem
Family: Enzyme
Novelty: 0.00375744
p_int: 0.813916918
p_ni: 0.186083032
p_wrong: 5e-8
Score: 0.308
Data Source: BioPlex,STRINGDB
CDC26
Tbio
Family: Enzyme
Novelty: 0.07456358
Score: 0.999
Data Source: STRINGDB
ANAPC4
Tbio
Family: Enzyme
Novelty: 0.28937094
Score: 0.999
Data Source: STRINGDB
ANAPC7
Tbio
Family: Enzyme
Novelty: 0.17956785
Score: 0.999
Data Source: STRINGDB
ANAPC2
Tbio
Family: Enzyme
Novelty: 0.19812984
Score: 0.999
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.11

PubMed score by year
PubTator Score  15.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: