Tbio ANAPC10 Anaphase-promoting complex subunit 10

Protein Summary

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

Uniprot Accession IDs

• Q9UM13
• D3DNZ7
• Q2V500
• Q9UG51
• Q9Y5R0
• APC10

Gene Name

• ANAPC10

Ensembl ID

• ENST00000309439
• ENSP00000310071
• ENSG00000164162
• ENST00000451299
• ENSP00000403891
• ENST00000507656
• ENSP00000423995
• ENST00000613466
• ENSP00000478501

Symbol

• APC10
• DOC1
• APC10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
virus perturbation	0.88
transcription factor binding site profile	0.85
kinase perturbation	0.84
histone modification site profile	0.83

Protein Classes

PANTHER Classes

Protein / Ligase / Anaphase-promoting Complex Subunit 10

Protein / Enzyme Modulator / Anaphase-promoting Complex Subunit 10

DTO Classes

Protein / Enzyme / Ligase / Anaphase-promoting Complex Subunit 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.79   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.79   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0