Tbio FZR1 Fizzy-related protein homolog

Protein Summary

Description

Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).

Uniprot Accession IDs

• Q9UM11
• O75869
• Q86U66
• Q96NW8
• Q9UI96
• Q9ULH8
• Q9UM10
• Q9UNQ1
• Q9Y2T8
• Fzr

Gene Name

• FZR1

Ensembl ID

• ENST00000313639
• ENSP00000321800
• ENSG00000105325
• ENST00000395095
• ENSP00000378529
• ENST00000441788
• ENSP00000410369

Symbol

• CDH1
• FYR
• FZR
• KIAA1242
• FZR
• CDH1
• FZR2
• HCDH
• HCDH1
• CDC20C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
biological process	0.91
small molecule perturbation	0.77
transcription factor	0.76
interacting protein	0.7

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Fizzy-related Protein Homolog

DTO Classes

Protein / Enzyme Modulator / Fizzy-related Protein Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.52   (req: < 5)

Gene RIFs: 79   (req: <= 3)

Antibodies: 317   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.52   (req: >= 5)

Gene RIFs: 79   (req: > 3)

Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0