Tchem PADI4 Protein-arginine deiminase type-4

Protein Summary

Description

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1. This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UM07
• A8K392
• B2RBW0
• Q5VTZ8
• Q70SX4

Gene Name

• PADI4

Ensembl ID

• ENST00000375448
• ENSP00000364597
• ENSG00000159339
• ENST00000628229
• ENSP00000487021
• ENSG00000280908

Symbol

• PAD4
• PADI5
• PDI5
• PAD
• PAD4
• PDI4
• PDI5
• PADI5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.79
biological term	0.74
protein domain	0.73
tissue sample	0.59
PubMedID	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.95   (req: < 5)

Gene RIFs: 174   (req: <= 3)

Antibodies: 453   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.95   (req: >= 5)

Gene RIFs: 174   (req: > 3)

Antibodies: 453   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0