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Tbio
SLC7A7
Y+L amino acid transporter 1

Protein Summary
Description
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285850
  • ENSP00000285850
  • ENSG00000155465
  • ENST00000397528
  • ENSP00000380662
  • ENST00000397529
  • ENSP00000380663
  • ENST00000397532
  • ENSP00000380666
  • ENST00000555702
  • ENSP00000451881

Symbol
  • LPI
  • LAT3
  • MOP-2
  • Y+LAT1
  • y+LAT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
PubMedID
0.92
gene perturbation
0.74
transcription factor binding site profile
0.73
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.6   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.6   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
Score:  0.983
Data Source:  Reactome,STRINGDB
BSG
Tbio
Novelty:  0.0010285
Score:  0.902
Data Source:  STRINGDB
CEP104
Tbio
Novelty:  0.07564892
Score:  0.81
Data Source:  STRINGDB
SLC3A1
Tbio
Family:  Transporter
Novelty:  0.003328
Score:  0.773
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.735
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.688
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.635
Data Source:  STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
Score:  0.632
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.605
Data Source:  STRINGDB
SLC6A14
Tchem
Family:  Transporter
Novelty:  0.02711393
Score:  0.598
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Basigin interactions
Cell surface interactions at the vascular wall
Defective SLC7A7 causes lysinuric protein intolerance (LPI)
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
84.7
heel bone mineral density
3
1
3
81.2
cup-to-disc ratio measurement
2
2
2
78.7
self reported educational attainment
3
3
2
5.7
72
Dupuytren Contracture
1
1
0
1.3
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
84.7
heel bone mineral density
3
81.2
cup-to-disc ratio measurement
2
78.7
self reported educational attainment
2
5.7
72
Dupuytren Contracture
0
1.3
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 7
VGNC:12534
452786
Macaque
solute carrier family 7 member 7
712466
Mouse
MGI:1337120
20540
Rat
RGD:619902
83509
Dog
solute carrier family 7 member 7
VGNC:46477
490602
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 7
Macaque
solute carrier family 7 member 7
Mouse
Rat
Dog
solute carrier family 7 member 7
Publication Statistics
PubMed Score 75.60
PubMed score by year
PubTator Score 68.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title