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Tchem
MMP17
Matrix metalloproteinase-17

Protein Summary
Description
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell sur ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360564
  • ENSP00000353767
  • ENSG00000198598
  • ENST00000535291
  • ENSP00000441106

Symbol
  • MT4MMP
  • MMP-17
  • MT4MMP
  • MTMMP4
  • MT4-MMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.63
molecular function
0.63
PubMedID
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.28   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.28   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (49)
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
Score:  0.973
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.944
Data Source:  STRINGDB
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
Score:  0.91
Data Source:  STRINGDB
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.827
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.713
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.638
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.613
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.599
Data Source:  STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
Score:  0.595
Data Source:  STRINGDB
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
Score:  0.593
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
57.1
red blood cell distribution width
3
1
3
47.4
self reported educational attainment
1
1
1
42.3
mean corpuscular volume
1
1
1
34.9
mean reticulocyte volume
1
1
1
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
57.1
red blood cell distribution width
3
47.4
self reported educational attainment
1
42.3
mean corpuscular volume
1
34.9
mean reticulocyte volume
1
34.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 17
VGNC:5480
452375
Macaque
matrix metallopeptidase 17
100430708
Mouse
MGI:1346076
23948
Rat
RGD:1311541
288626
Horse
matrix metallopeptidase 17
VGNC:20227
100062342
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 17
Macaque
matrix metallopeptidase 17
Mouse
Rat
Horse
matrix metallopeptidase 17
Publication Statistics
PubMed Score 33.28
PubMed score by year
PubTator Score 29.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title