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Tbio
PYCARD
Apoptosis-associated speck-like protein containing a CARD

Protein Summary
Description
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the py ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247470
  • ENSP00000247470
  • ENSG00000103490
  • ENST00000350605
  • ENSP00000340441

Symbol
  • ASC
  • CARD5
  • TMS1
  • ASC
  • TMS
  • TMS1
  • CARD5
  • TMS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
0.91
virus perturbation
0.83
PubMedID
0.82
biological term
0.8


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.04   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.04   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PYD and CARD domain containing
VGNC:5905
742444
Macaque
PYD and CARD domain containing
713563
Mouse
MGI:1931465
66824
Rat
RGD:628637
282817
Horse
apoptosis-associated speck-like protein containing a CARD
100063252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PYD and CARD domain containing
Macaque
PYD and CARD domain containing
Mouse
Rat
Horse
apoptosis-associated speck-like protein containing a CARD
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULZ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
CLEC7A/inflammasome pathway
Reactome
Immune System
Reactome
Inflammasomes
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
CLEC7A/inflammasome pathway
Immune System
Inflammasomes
Gene Ontology Terms (84)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Physical Interaction (IPI)
AgBase
Protein-Protein Interactions (203)
1 – 10 of 203
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.9998961
p_ni: 0.000103897
p_wrong: 3e-9
Data Source: BioPlex
ZYG11B
Tbio
Novelty: 0.14657862
p_int: 0.999890889
p_ni: 0.000109111
Score: 0.183
Data Source: BioPlex,STRINGDB
PIGP
Tbio
Family: Enzyme
Novelty: 0.01400934
p_int: 0.999876951
p_ni: 0.000123046
p_wrong: 3e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
BIRC5
Tchem
Novelty: 0.00332112
p_int: 0.999395489
p_ni: 0.000594992
p_wrong: 0.00000952
Score: 0.256
Data Source: BioPlex,STRINGDB
CUL2
Tbio
Novelty: 0.00512916
p_int: 0.995776274
p_ni: 0.004223726
Score: 0.159
Data Source: BioPlex,STRINGDB
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.994644824
p_ni: 0.005346104
p_wrong: 0.000009072
Data Source: BioPlex
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.997
Data Source: Reactome,STRINGDB
NLRP3
Tchem
Novelty: 0.00043957
Score: 0.996
Data Source: Reactome,STRINGDB
AIM2
Tbio
Novelty: 0.00360474
Score: 0.988
Data Source: Reactome,STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.982
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  91.04

PubMed score by year
PubTator Score  976.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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