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Tbio
PYCARD
Apoptosis-associated speck-like protein containing a CARD

Protein Summary
Description
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the py ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247470
  • ENSP00000247470
  • ENSG00000103490
  • ENST00000350605
  • ENSP00000340441

Symbol
  • ASC
  • CARD5
  • TMS1
  • ASC
  • TMS
  • TMS1
  • CARD5
  • TMS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
0.91
virus perturbation
0.83
PubMedID
0.82
biological term
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.25   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.25   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.9998961
p_ni:  0.000103897
p_wrong:  3e-9
Data Source:  BioPlex
ZYG11B
Tbio
Novelty:  0.14657862
p_int:  0.999890889
p_ni:  0.000109111
Score:  0.183
Data Source:  BioPlex,STRINGDB
PIGP
Tbio
Family:  Enzyme
Novelty:  0.01400934
p_int:  0.999876951
p_ni:  0.000123046
p_wrong:  3e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
BIRC5
Tchem
Novelty:  0.00332112
p_int:  0.999395489
p_ni:  0.000594992
p_wrong:  0.00000952
Score:  0.256
Data Source:  BioPlex,STRINGDB
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.995776274
p_ni:  0.004223726
Score:  0.159
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.994644824
p_ni:  0.005346104
p_wrong:  0.000009072
Data Source:  BioPlex
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.997
Data Source:  Reactome,STRINGDB
NLRP3
Tchem
Novelty:  0.00043957
Score:  0.996
Data Source:  Reactome,STRINGDB
AIM2
Tbio
Novelty:  0.00360474
Score:  0.988
Data Source:  Reactome,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.982
Data Source:  Reactome,STRINGDB
Pathways (24)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
CLEC7A/inflammasome pathway
Reactome
Immune System
Reactome
Inflammasomes
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
CLEC7A/inflammasome pathway
Immune System
Inflammasomes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (84)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Physical Interaction (IPI)
AgBase
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
0
1.7
99.4
waist circumference
2
2
2
78.6
Parkinson disease
2
1
0
1.1
77.3
IGF-1 measurement
1
4
4
77.1
body mass index
4
1
5
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
99.4
waist circumference
2
78.6
Parkinson disease
0
1.1
77.3
IGF-1 measurement
4
77.1
body mass index
5
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PYD and CARD domain containing
VGNC:5905
742444
Macaque
PYD and CARD domain containing
713563
Mouse
MGI:1931465
66824
Rat
RGD:628637
282817
Horse
apoptosis-associated speck-like protein containing a CARD
100063252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PYD and CARD domain containing
Macaque
PYD and CARD domain containing
Mouse
Rat
Horse
apoptosis-associated speck-like protein containing a CARD
Publication Statistics
PubMed Score 120.25
PubMed score by year
PubTator Score 976.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title